Exploratory differential gene expression analysis in microarray experiments with no or limited replication

We describe an exploratory, data-oriented approach for identifying candidates for differential gene expression in cDNA microarray experiments in terms of α-outliers and outlier regions, using simultaneous tolerance intervals relative to the line of equivalence (Cy5 = Cy3). We demonstrate the improve...

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Detalles Bibliográficos
Autores principales: Loguinov, Alexander V, Mian, I Saira, Vulpe, Chris D
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC395768/
https://www.ncbi.nlm.nih.gov/pubmed/15003121
http://dx.doi.org/10.1186/gb-2004-5-3-r18
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author Loguinov, Alexander V
Mian, I Saira
Vulpe, Chris D
author_facet Loguinov, Alexander V
Mian, I Saira
Vulpe, Chris D
author_sort Loguinov, Alexander V
collection PubMed
description We describe an exploratory, data-oriented approach for identifying candidates for differential gene expression in cDNA microarray experiments in terms of α-outliers and outlier regions, using simultaneous tolerance intervals relative to the line of equivalence (Cy5 = Cy3). We demonstrate the improved performance of our approach over existing single-slide methods using public datasets and simulation studies.
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spelling pubmed-3957682004-04-24 Exploratory differential gene expression analysis in microarray experiments with no or limited replication Loguinov, Alexander V Mian, I Saira Vulpe, Chris D Genome Biol Method We describe an exploratory, data-oriented approach for identifying candidates for differential gene expression in cDNA microarray experiments in terms of α-outliers and outlier regions, using simultaneous tolerance intervals relative to the line of equivalence (Cy5 = Cy3). We demonstrate the improved performance of our approach over existing single-slide methods using public datasets and simulation studies. BioMed Central 2004 2004-03-01 /pmc/articles/PMC395768/ /pubmed/15003121 http://dx.doi.org/10.1186/gb-2004-5-3-r18 Text en Copyright © 2004 Loguinov et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
spellingShingle Method
Loguinov, Alexander V
Mian, I Saira
Vulpe, Chris D
Exploratory differential gene expression analysis in microarray experiments with no or limited replication
title Exploratory differential gene expression analysis in microarray experiments with no or limited replication
title_full Exploratory differential gene expression analysis in microarray experiments with no or limited replication
title_fullStr Exploratory differential gene expression analysis in microarray experiments with no or limited replication
title_full_unstemmed Exploratory differential gene expression analysis in microarray experiments with no or limited replication
title_short Exploratory differential gene expression analysis in microarray experiments with no or limited replication
title_sort exploratory differential gene expression analysis in microarray experiments with no or limited replication
topic Method
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC395768/
https://www.ncbi.nlm.nih.gov/pubmed/15003121
http://dx.doi.org/10.1186/gb-2004-5-3-r18
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