Green Fluorescent Diamidines as Diagnostic Probes for Trypanosomes

Light-emitting diode (LED) fluorescence microscopy offers potential benefits in the diagnosis of human African trypanosomiasis and in other aspects of diseases management, such as detection of drug-resistant strains. To advance such approaches, reliable and specific fluorescent markers to stain para...

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Detalles Bibliográficos
Autores principales: Giordani, Federica, Munde, Manoj, Wilson, W. David, Ismail, Mohamed A., Kumar, Arvind, Boykin, David W., Barrett, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2014
Materias:
Chemistry; Biosynthesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957857/
https://www.ncbi.nlm.nih.gov/pubmed/24366732
http://dx.doi.org/10.1128/AAC.02024-13
Descripción
Sumario:Light-emitting diode (LED) fluorescence microscopy offers potential benefits in the diagnosis of human African trypanosomiasis and in other aspects of diseases management, such as detection of drug-resistant strains. To advance such approaches, reliable and specific fluorescent markers to stain parasites in human fluids are needed. Here we describe a series of novel green fluorescent diamidines and their suitability as probes with which to stain trypanosomes.

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