Green Fluorescent Diamidines as Diagnostic Probes for Trypanosomes

Light-emitting diode (LED) fluorescence microscopy offers potential benefits in the diagnosis of human African trypanosomiasis and in other aspects of diseases management, such as detection of drug-resistant strains. To advance such approaches, reliable and specific fluorescent markers to stain para...

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Detalles Bibliográficos
Autores principales: Giordani, Federica, Munde, Manoj, Wilson, W. David, Ismail, Mohamed A., Kumar, Arvind, Boykin, David W., Barrett, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2014
Materias:
Chemistry; Biosynthesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957857/
https://www.ncbi.nlm.nih.gov/pubmed/24366732
http://dx.doi.org/10.1128/AAC.02024-13
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author Giordani, Federica
Munde, Manoj
Wilson, W. David
Ismail, Mohamed A.
Kumar, Arvind
Boykin, David W.
Barrett, Michael P.
author_facet Giordani, Federica
Munde, Manoj
Wilson, W. David
Ismail, Mohamed A.
Kumar, Arvind
Boykin, David W.
Barrett, Michael P.
author_sort Giordani, Federica
collection PubMed
description Light-emitting diode (LED) fluorescence microscopy offers potential benefits in the diagnosis of human African trypanosomiasis and in other aspects of diseases management, such as detection of drug-resistant strains. To advance such approaches, reliable and specific fluorescent markers to stain parasites in human fluids are needed. Here we describe a series of novel green fluorescent diamidines and their suitability as probes with which to stain trypanosomes.
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spelling pubmed-39578572014-04-10 Green Fluorescent Diamidines as Diagnostic Probes for Trypanosomes Giordani, Federica Munde, Manoj Wilson, W. David Ismail, Mohamed A. Kumar, Arvind Boykin, David W. Barrett, Michael P. Antimicrob Agents Chemother Chemistry; Biosynthesis Light-emitting diode (LED) fluorescence microscopy offers potential benefits in the diagnosis of human African trypanosomiasis and in other aspects of diseases management, such as detection of drug-resistant strains. To advance such approaches, reliable and specific fluorescent markers to stain parasites in human fluids are needed. Here we describe a series of novel green fluorescent diamidines and their suitability as probes with which to stain trypanosomes. American Society for Microbiology 2014-03 /pmc/articles/PMC3957857/ /pubmed/24366732 http://dx.doi.org/10.1128/AAC.02024-13 Text en Copyright © 2014 Giordani et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) .
spellingShingle Chemistry; Biosynthesis
Giordani, Federica
Munde, Manoj
Wilson, W. David
Ismail, Mohamed A.
Kumar, Arvind
Boykin, David W.
Barrett, Michael P.
Green Fluorescent Diamidines as Diagnostic Probes for Trypanosomes
title Green Fluorescent Diamidines as Diagnostic Probes for Trypanosomes
title_full Green Fluorescent Diamidines as Diagnostic Probes for Trypanosomes
title_fullStr Green Fluorescent Diamidines as Diagnostic Probes for Trypanosomes
title_full_unstemmed Green Fluorescent Diamidines as Diagnostic Probes for Trypanosomes
title_short Green Fluorescent Diamidines as Diagnostic Probes for Trypanosomes
title_sort green fluorescent diamidines as diagnostic probes for trypanosomes
topic Chemistry; Biosynthesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957857/
https://www.ncbi.nlm.nih.gov/pubmed/24366732
http://dx.doi.org/10.1128/AAC.02024-13
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