Cargando…

Design Principles of Concentration-Dependent Transcriptome Deviations in Drug-Exposed Differentiating Stem Cells

[Image: see text] Information on design principles governing transcriptome changes upon transition from safe to hazardous drug concentrations or from tolerated to cytotoxic drug levels are important for the application of toxicogenomics data in developmental toxicology. Here, we tested the effect of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Waldmann, Tanja, Rempel, Eugen, Balmer, Nina V., König, André, Kolde, Raivo, Gaspar, John Antonydas, Henry, Margit, Hescheler, Jürgen, Sachinidis, Agapios, Rahnenführer, Jörg, Hengstler, Jan G., Leist, Marcel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958134/ https://www.ncbi.nlm.nih.gov/pubmed/24383497 http://dx.doi.org/10.1021/tx400402j

Ejemplares similares

From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects
por: Balmer, Nina V., et al.
Publicado: (2014)

Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration
por: Pallocca, Giorgia, et al.
Publicado: (2015)

MicroRNAs as early toxicity signatures of doxorubicin in human-induced pluripotent stem cell-derived cardiomyocytes
por: Chaudhari, Umesh, et al.
Publicado: (2016)

Comparison of a teratogenic transcriptome-based predictive test based on human embryonic versus inducible pluripotent stem cells
por: Shinde, Vaibhav, et al.
Publicado: (2016)

Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Tox(ukn) and STOP-Tox(ukk) tests
por: Shinde, Vaibhav, et al.
Publicado: (2016)

Kinetic modeling of stem cell transcriptome dynamics to identify regulatory modules of normal and disturbed neuroectodermal differentiation
por: Meisig, Johannes, et al.
Publicado: (2020)

A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors
por: Rempel, Eugen, et al.
Publicado: (2015)

High-efficient serum-free differentiation of endothelial cells from human iPS cells
por: Hamad, Sarkawt, et al.
Publicado: (2022)

Transcriptome-based prediction of drugs, inhibiting cardiomyogenesis in human induced pluripotent stem cells
por: Cherianidou, Anna, et al.
Publicado: (2023)

Impairment of human neural crest cell migration by prolonged exposure to interferon-beta
por: Pallocca, Giorgia, et al.
Publicado: (2017)

Depletion of Mageb16 induces differentiation of pluripotent stem cells predominantly into mesodermal derivatives
por: Gaspar, John Antonydas, et al.
Publicado: (2017)

Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach
por: Krug, Anne K., et al.
Publicado: (2012)

Classification of Developmental Toxicants in a Human iPSC Transcriptomics-Based Test
por: Cherianidou, Anna, et al.
Publicado: (2022)

Handling deviating control values in concentration-response curves
por: Kappenberg, Franziska, et al.
Publicado: (2020)

Lineage-Specific Regulation of Epigenetic Modifier Genes in Human Liver and Brain
por: Weng, Matthias K., et al.
Publicado: (2014)

Identification of Thalidomide-Specific Transcriptomics and Proteomics Signatures during Differentiation of Human Embryonic Stem Cells
por: Meganathan, Kesavan, et al.
Publicado: (2012)

High Accuracy Classification of Developmental Toxicants by In Vitro Tests of Human Neuroepithelial and Cardiomyoblast Differentiation
por: Seidel, Florian, et al.
Publicado: (2022)

Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment
por: Chaudhari, Umesh, et al.
Publicado: (2015)

Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells
por: Nemade, Harshal, et al.
Publicado: (2018)

Modulation of Differentiation Processes in Murine Embryonic Stem Cells Exposed to Parabolic Flight-Induced Acute Hypergravity and Microgravity
por: Acharya, Aviseka, et al.
Publicado: (2018)

Cardiovascular genomics: A current overview of in vivo and in vitro studies
por: Mariappan, Devi, et al.
Publicado: (2006)

Three LIF-dependent signatures and gene clusters with atypical expression profiles, identified by transcriptome studies in mouse ES cells and early derivatives
por: Trouillas, Marina, et al.
Publicado: (2009)

Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes
por: Chaudhari, Umesh, et al.
Publicado: (2017)

STRIP2 Is Indispensable for the Onset of Embryonic Stem Cell Differentiation
por: Sabour, Davood, et al.
Publicado: (2017)

EDI3 links choline metabolism to integrin expression, cell adhesion and spreading
por: Lesjak, Michaela S, et al.
Publicado: (2014)

Extensive Transcriptional Regulation of Chromatin Modifiers during Human Neurodevelopment
por: Weng, Matthias K., et al.
Publicado: (2012)

Neuronal developmental gene and miRNA signatures induced by histone deacetylase inhibitors in human embryonic stem cells
por: Meganathan, K, et al.
Publicado: (2015)

Evaluation of Developmental Toxicants and Signaling Pathways in a Functional Test Based on the Migration of Human Neural Crest Cells
por: Zimmer, Bastian, et al.
Publicado: (2012)

Neuronal-Specific Deficiency of the Splicing Factor Tra2b Causes Apoptosis in Neurogenic Areas of the Developing Mouse Brain
por: Storbeck, Markus, et al.
Publicado: (2014)

Distinct transcriptomic changes in E14.5 mouse skeletal muscle lacking RYR1 or Ca(v)1.1 converge at E18.5
por: Filipova, Dilyana, et al.
Publicado: (2018)

First steps towards the successful surface-based cultivation of human embryonic stem cells in hanging drop systems
por: Schulz, Julia C, et al.
Publicado: (2012)

Parabolic, Flight-Induced, Acute Hypergravity and Microgravity Effects on the Beating Rate of Human Cardiomyocytes
por: Acharya, Aviseka, et al.
Publicado: (2019)

Metabolite signatures of doxorubicin induced toxicity in human induced pluripotent stem cell-derived cardiomyocytes
por: Chaudhari, Umesh, et al.
Publicado: (2017)

Persistence of intramyocardially transplanted murine induced pluripotent stem cell-derived cardiomyocytes from different developmental stages
por: Peinkofer, Gabriel, et al.
Publicado: (2021)

From smoking guns to footprints: mining for critical events of toxicity pathways in transcriptome data
por: Rahnenführer, Jörg, et al.
Publicado: (2015)

Live-Cell Imaging of the Contractile Velocity and Transient Intracellular Ca(2+) Fluctuations in Human Stem Cell-Derived Cardiomyocytes
por: Acharya, Aviseka, et al.
Publicado: (2022)

Highlight report: Cardiotoxicity screening
por: Sachinidis, Agapios
Publicado: (2016)

Cardiotoxicity and Heart Failure: Lessons from Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Anticancer Drugs
por: Sachinidis, Agapios
Publicado: (2020)

High-throughput base editing: a promising technology for precision medicine and drug discovery
por: Sachinidis, Agapios
Publicado: (2021)

Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay
por: Colaianna, Marilena, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_o1so7fmrbvqbv9dnkds9007ant