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Anti dermatophytic therapy - Prospects for the discovery of new drugs from natural products
Millions of people and animals suffer from superficial infections caused by a group of highly specialized filamentous fungi, the dermatophytes, which only infect keratinized structures. With the appearance of AIDS, the incidence of dermatophytosis has increased. Current drug therapy used for these i...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Brazilian Society of Microbiology
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958166/ https://www.ncbi.nlm.nih.gov/pubmed/24688490 http://dx.doi.org/10.1590/S1517-83822014005000011 |
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author | Soares, Luciana Arantes de Cássia Orlandi Sardi, Janaína Gullo, Fernanda Patrícia de Souza Pitangui, Nayla Scorzoni, Liliana Leite, Fernanda Sangalli Giannini, Maria José Soares Mendes Almeida, Ana Marisa Fusco |
author_facet | Soares, Luciana Arantes de Cássia Orlandi Sardi, Janaína Gullo, Fernanda Patrícia de Souza Pitangui, Nayla Scorzoni, Liliana Leite, Fernanda Sangalli Giannini, Maria José Soares Mendes Almeida, Ana Marisa Fusco |
author_sort | Soares, Luciana Arantes |
collection | PubMed |
description | Millions of people and animals suffer from superficial infections caused by a group of highly specialized filamentous fungi, the dermatophytes, which only infect keratinized structures. With the appearance of AIDS, the incidence of dermatophytosis has increased. Current drug therapy used for these infections is often toxic, long-term, and expensive and has limited effectiveness; therefore, the discovery of new anti dermatophytic compounds is a necessity. Natural products have been the most productive source for new drug development. This paper provides a brief review of the current literature regarding the presence of dermatophytes in immunocompromised patients, drug resistance to conventional treatments and new anti dermatophytic treatments. |
format | Online Article Text |
id | pubmed-3958166 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Brazilian Society of Microbiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-39581662014-04-10 Anti dermatophytic therapy - Prospects for the discovery of new drugs from natural products Soares, Luciana Arantes de Cássia Orlandi Sardi, Janaína Gullo, Fernanda Patrícia de Souza Pitangui, Nayla Scorzoni, Liliana Leite, Fernanda Sangalli Giannini, Maria José Soares Mendes Almeida, Ana Marisa Fusco Braz J Microbiol Review Millions of people and animals suffer from superficial infections caused by a group of highly specialized filamentous fungi, the dermatophytes, which only infect keratinized structures. With the appearance of AIDS, the incidence of dermatophytosis has increased. Current drug therapy used for these infections is often toxic, long-term, and expensive and has limited effectiveness; therefore, the discovery of new anti dermatophytic compounds is a necessity. Natural products have been the most productive source for new drug development. This paper provides a brief review of the current literature regarding the presence of dermatophytes in immunocompromised patients, drug resistance to conventional treatments and new anti dermatophytic treatments. Brazilian Society of Microbiology 2014-03-10 /pmc/articles/PMC3958166/ /pubmed/24688490 http://dx.doi.org/10.1590/S1517-83822014005000011 Text en Copyright © 2013, Sociedade Brasileira de Microbiologia All the content of the journal, except where otherwise noted, is licensed under a Creative Commons License CC BY-NC. |
spellingShingle | Review Soares, Luciana Arantes de Cássia Orlandi Sardi, Janaína Gullo, Fernanda Patrícia de Souza Pitangui, Nayla Scorzoni, Liliana Leite, Fernanda Sangalli Giannini, Maria José Soares Mendes Almeida, Ana Marisa Fusco Anti dermatophytic therapy - Prospects for the discovery of new drugs from natural products |
title | Anti dermatophytic therapy - Prospects for the discovery of new drugs from natural products |
title_full | Anti dermatophytic therapy - Prospects for the discovery of new drugs from natural products |
title_fullStr | Anti dermatophytic therapy - Prospects for the discovery of new drugs from natural products |
title_full_unstemmed | Anti dermatophytic therapy - Prospects for the discovery of new drugs from natural products |
title_short | Anti dermatophytic therapy - Prospects for the discovery of new drugs from natural products |
title_sort | anti dermatophytic therapy - prospects for the discovery of new drugs from natural products |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958166/ https://www.ncbi.nlm.nih.gov/pubmed/24688490 http://dx.doi.org/10.1590/S1517-83822014005000011 |
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