VEGF-B: a more balanced approach toward cardiac neovascularization?

There is an urgent need for new pharmacologic approaches to combat the clinical consequences of ischemic cardiomyopathy. In this issue of EMBO Molecular Medicine, Kivelä et al show that transgenic expression of VEGF-B in the rat heart leads to expansion of the coronary arterial tree and an increase...

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Detalles Bibliográficos
Autores principales: Kupatt, Christian, Hinkel, Rabea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958304/
https://www.ncbi.nlm.nih.gov/pubmed/24521742
http://dx.doi.org/10.1002/emmm.201303730
Descripción
Sumario:There is an urgent need for new pharmacologic approaches to combat the clinical consequences of ischemic cardiomyopathy. In this issue of EMBO Molecular Medicine, Kivelä et al show that transgenic expression of VEGF-B in the rat heart leads to expansion of the coronary arterial tree and an increase in functional coronary reserve, accompanied by a shift in myocardial metabolism from fatty acid to glucose utilization. See also: R Kivelä et al (March 2014)

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