VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart

Angiogenic growth factors have recently been linked to tissue metabolism. We have used genetic gain- and loss-of function models to elucidate the effects and mechanisms of action of vascular endothelial growth factor-B (VEGF-B) in the heart. A cardiomyocyte-specific VEGF-B transgene induced an expan...

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Detalles Bibliográficos
Autores principales: Kivelä, Riikka, Bry, Maija, Robciuc, Marius R, Räsänen, Markus, Taavitsainen, Miia, Silvola, Johanna MU, Saraste, Antti, Hulmi, Juha J, Anisimov, Andrey, Mäyränpää, Mikko I, Lindeman, Jan H, Eklund, Lauri, Hellberg, Sanna, Hlushchuk, Ruslan, Zhuang, Zhen W, Simons, Michael, Djonov, Valentin, Knuuti, Juhani, Mervaala, Eero, Alitalo, Kari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958306/
https://www.ncbi.nlm.nih.gov/pubmed/24448490
http://dx.doi.org/10.1002/emmm.201303147

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