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A potent anti-dengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface
Dengue virus (DENV), which consists of four serotypes (DENV1-4), infects over 400 million people annually. Previous studies have indicated most human monoclonal antibodies (HMAbs) from dengue patients are cross-reactive and poorly neutralizing. Rare neutralizing HMAbs are usually serotype-specific a...
Autores principales: | Fibriansah, Guntur, Tan, Joanne L, Smith, Scott A, Alwis, Adamberage R, Ng, Thiam-Seng, Kostyuchenko, Victor A, Ibarra, Kristie D, Wang, Jiaqi, Harris, Eva, Silva, Aravinda, Crowe, James E, Lok, Shee-Mei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958310/ https://www.ncbi.nlm.nih.gov/pubmed/24421336 http://dx.doi.org/10.1002/emmm.201303404 |
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