Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury

Type 1 interferons (IFN) protect the host against viruses by engaging a cognate receptor (consisting of IFNAR1/IFNAR2 chains) and inducing downstream signaling and gene expression. However, inflammatory stimuli can trigger IFNAR1 ubiquitination and downregulation thereby attenuating IFN effects in v...

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Detalles Bibliográficos
Autores principales: Bhattacharya, Sabyasachi, Katlinski, Kanstantsin V, Reichert, Maximilian, Takano, Shigetsugu, Brice, Angela, Zhao, Bin, Yu, Qiujing, Zheng, Hui, Carbone, Christopher J, Katlinskaya, Yuliya V, Leu, N Adrian, McCorkell, Kelly A, Srinivasan, Satish, Girondo, Melanie, Rui, Hallgeir, May, Michael J, Avadhani, Narayan G, Rustgi, Anil K, Fuchs, Serge Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958312/
https://www.ncbi.nlm.nih.gov/pubmed/24480543
http://dx.doi.org/10.1002/emmm.201303236

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