Cargando…

Multiple Sporadic Colorectal Cancers Display a Unique Methylation Phenotype

Epigenetics are thought to play a major role in the carcinogenesis of multiple sporadic colorectal cancers (CRC). Previous studies have suggested concordant DNA hypermethylation between tumor pairs. However, only a few methylation markers have been analyzed. This study was aimed at describing the ep...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gonzalo, Victoria, Lozano, Juan Jose, Alonso-Espinaco, Virginia, Moreira, Leticia, Muñoz, Jenifer, Pellisé, Maria, Castellví-Bel, Sergi, Bessa, Xavier, Andreu, Montserrat, Xicola, Rosa M., Llor, Xavier, Ruiz-Ponte, Clara, Carracedo, Angel, Jover, Rodrigo, Castells, Antoni, Balaguer, Francesc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958343/ https://www.ncbi.nlm.nih.gov/pubmed/24643221 http://dx.doi.org/10.1371/journal.pone.0091033

Ejemplares similares

Aberrant Gene Promoter Methylation Associated with Sporadic Multiple Colorectal Cancer
por: Gonzalo, Victoria, et al.
Publicado: (2010)

Single Nucleotide Polymorphisms in the Wnt and BMP Pathways and Colorectal Cancer Risk in a Spanish Cohort
por: Fernández-Rozadilla, Ceres, et al.
Publicado: (2010)

Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins
por: Abulí, Anna, et al.
Publicado: (2011)

A colorectal cancer genome-wide association study in a Spanish cohort identifies two variants associated with colorectal cancer risk at 1p33 and 8p12
por: Fernandez-Rozadilla, Ceres, et al.
Publicado: (2013)

Molecular analysis of the APC and MUTYH genes in Galician and Catalonian FAP families: a different spectrum of mutations?
por: Gómez-Fernández, Nuria, et al.
Publicado: (2009)

Whole-exome sequencing identifies rare pathogenic variants in new predisposition genes for familial colorectal cancer
por: Esteban-Jurado, Clara, et al.
Publicado: (2015)

Genetic Variants Associated with Colorectal Adenoma Susceptibility
por: Abulí, Anna, et al.
Publicado: (2016)

xDEEP-MSI: Explainable Bias-Rejecting Microsatellite Instability Deep Learning System in Colorectal Cancer
por: Bustos, Aurelia, et al.
Publicado: (2021)

The MLH1 c.1852_1853delinsGC (p.K618A) Variant in Colorectal Cancer: Genetic Association Study in 18,723 Individuals
por: Abulí, Anna, et al.
Publicado: (2014)

A High Degree of LINE-1 Hypomethylation Is a Unique Feature of Early-Onset Colorectal Cancer
por: Antelo, Marina, et al.
Publicado: (2012)

IGFBP3 Methylation Is a Novel Diagnostic and Predictive Biomarker in Colorectal Cancer
por: Perez-Carbonell, Lucia, et al.
Publicado: (2014)

Unraveling the impact of a germline heterozygous POLD1 frameshift variant in serrated polyposis syndrome
por: Bonjoch, Laia, et al.
Publicado: (2023)

LINE-1 hypomethylation is neither present in rectal aberrant crypt foci nor associated with field defect in sporadic colorectal neoplasia
por: Quintanilla, Isabel, et al.
Publicado: (2014)

Exome sequencing of early-onset patients supports genetic heterogeneity in colorectal cancer
por: Fernández-Rozadilla, C., et al.
Publicado: (2021)

Rectal Aberrant Crypt Foci in Humans Are Not Surrogate Markers for Colorectal Cancer Risk
por: Quintanilla, Isabel, et al.
Publicado: (2019)

Pharmacogenomics of CRC treatments: putting bricks on the path to personalized medicine
por: Fernández-Rozadilla, Ceres, et al.
Publicado: (2014)

Efficacy of Adjuvant 5-Fluorouracil Therapy for Patients with EMAST-Positive Stage II/III Colorectal Cancer
por: Hamaya, Yasushi, et al.
Publicado: (2015)

A two-phase case–control study for colorectal cancer genetic susceptibility: candidate genes from chromosomal regions 9q22 and 3q22
por: Abulí, A, et al.
Publicado: (2011)

Accuracy of Colon Capsule Endoscopy in Detecting Colorectal Polyps in Individuals with Familial Colorectal Cancer: Could We Avoid Colonoscopies?
por: Alvarez-Urturi, Cristina, et al.
Publicado: (2017)

The Fanconi anemia DNA damage repair pathway in the spotlight for germline predisposition to colorectal cancer
por: Esteban-Jurado, Clara, et al.
Publicado: (2016)

Colorectal cancer genetic variants are also associated with serrated polyposis syndrome susceptibility
por: Arnau-Collell, Coral, et al.
Publicado: (2020)

Identification of New Genes Involved in Germline Predisposition to Early-Onset Gastric Cancer
por: Herrera-Pariente, Cristina, et al.
Publicado: (2021)

Identification of Lynch Syndrome Carriers among Patients with Small Bowel Adenocarcinoma
por: Sánchez, Ariadna, et al.
Publicado: (2021)

Comprehensive Genomic Characterization of Fifteen Early-Onset Lynch-Like Syndrome Colorectal Cancers
por: Golubicki, Mariano, et al.
Publicado: (2021)

Lymph node pooling: a feasible and efficient method of lymph node molecular staging in colorectal carcinoma
por: Rakislova, Natalia, et al.
Publicado: (2017)

Genetic Associations in the Vitamin D Receptor and Colorectal Cancer in African Americans and Caucasians
por: Kupfer, Sonia S., et al.
Publicado: (2011)

Using linkage studies combined with whole‐exome sequencing to identify novel candidate genes for familial colorectal cancer
por: Toma, Claudio, et al.
Publicado: (2019)

Evidence for classification of c.1852_1853AA>GC in MLH1 as a neutral variant for Lynch syndrome
por: Castillejo, Adela, et al.
Publicado: (2011)

Association between socioeconomic deprivation and colorectal cancer screening outcomes: Low uptake rates among the most and least deprived people
por: Buron, Andrea, et al.
Publicado: (2017)

Pancreatic Cancer Surveillance in Carriers of a Germline Pathogenic Variant in CDKN2A
por: Llach, Joan, et al.
Publicado: (2023)

Germline and Somatic Whole-Exome Sequencing Identifies New Candidate Genes Involved in Familial Predisposition to Serrated Polyposis Syndrome
por: Soares de Lima, Yasmin, et al.
Publicado: (2021)

Colorectal cancer after negative colonoscopy in fecal immunochemical test-positive participants from a colorectal cancer screening program
por: Rivero-Sánchez, Liseth, et al.
Publicado: (2018)

Integrated Analysis of Germline and Tumor DNA Identifies New Candidate Genes Involved in Familial Colorectal Cancer
por: Díaz-Gay, Marcos, et al.
Publicado: (2019)

POLE and POLD1 screening in 155 patients with multiple polyps and early-onset colorectal cancer
por: Esteban-Jurado, Clara, et al.
Publicado: (2017)

Quantitative analysis of somatically acquired and constitutive uniparental disomy in gastrointestinal cancers
por: Torabi, Keyvan, et al.
Publicado: (2018)

Germline biallelic Mcm8 variants are associated with early-onset Lynch-like syndrome
por: Golubicki, Mariano, et al.
Publicado: (2020)

Identification of a Novel Candidate Gene for Serrated Polyposis Syndrome Germline Predisposition by Performing Linkage Analysis Combined With Whole-Exome Sequencing
por: Toma, Claudio, et al.
Publicado: (2019)

Genetic Counseling for Hereditary Gastric and Pancreatic Cancer in High-Risk Gastrointestinal Cancer Clinics: An Effective Strategy
por: Llach, Joan, et al.
Publicado: (2020)

Colorectal cancer molecular classification using BRAF, KRAS, microsatellite instability and CIMP status: Prognostic implications and response to chemotherapy
por: Murcia, Oscar, et al.
Publicado: (2018)

Differentially Deregulated MicroRNAs as Novel Biomarkers for Neoplastic Progression in Ulcerative Colitis
por: Quintanilla, Isabel, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_socd0a8nfcl28jtcaofh79nckt