Downregulation of ROCK2 through Nanocomplex Sensitizes the Cytotoxic Effect of Temozolomide in U251 Glioma Cells

OBJECTIVE: Rho-associated coiled-coil kinase 2 (ROCK2) is an attractive therapeutic target because it is overexpressed in many malignancies, including glioma. Therefore, we designed the current study to determine whether the downregulation of ROCK2 would sensitize the cytotoxic effect of temozolomid...

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Detalles Bibliográficos
Autores principales: Wen, Xiaojun, Huang, Amin, Liu, Zhonglin, Liu, Yunyun, Hu, Jingyang, Liu, Jun, Shuai, Xintao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958422/
https://www.ncbi.nlm.nih.gov/pubmed/24642531
http://dx.doi.org/10.1371/journal.pone.0092050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958422/
https://www.ncbi.nlm.nih.gov/pubmed/24642531
http://dx.doi.org/10.1371/journal.pone.0092050

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