Increased Frequency of Tim-3 Expressing T Cells Is Associated with Symptomatic West Nile Virus Infection

More than a decade after West Nile virus (WNV) entered North America, and despite a significant increase in reported cases during the 2012 and 2013 seasons, no treatment or vaccine for humans is available. Although antiviral T cells contribute to the control of WNV, little is known about their regul...

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Detalles Bibliográficos
Autores principales: Lanteri, Marion C., Diamond, Michael S., Law, Jacqueline P., Chew, Glen M., Wu, Shiquan, Inglis, Heather C., Wong, Derek, Busch, Michael P., Norris, Philip J., Ndhlovu, Lishomwa C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958446/
https://www.ncbi.nlm.nih.gov/pubmed/24642562
http://dx.doi.org/10.1371/journal.pone.0092134
Descripción
Sumario:More than a decade after West Nile virus (WNV) entered North America, and despite a significant increase in reported cases during the 2012 and 2013 seasons, no treatment or vaccine for humans is available. Although antiviral T cells contribute to the control of WNV, little is known about their regulation during acute infection. We analyzed the expression of Tim-3 and PD-1, two recently identified T cell negative immune checkpoint receptors, over the course of WNV infection. Symptomatic WNV+ donors exhibited higher frequencies of Tim-3(+) cells than asymptomatic subjects within naïve/early differentiated CD28(+/–)CD57(–)CD4(+) and differentiated CD28(–)CD57(–)CD8(+) T cells. Our study links Tim-3-expression on T cells during acute WNV infection with the development of symptomatic disease, suggesting Tim-3 and its ligands could be targeted therapeutically to alter anti-WNV immunity and improve disease outcome.

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