Ceramide Transfer Protein Deficiency Compromises Organelle Function and Leads to Senescence in Primary Cells

Ceramide transfer protein (CERT) transfers ceramide from the endoplasmic reticulum (ER) to the Golgi complex. Its deficiency in mouse leads to embryonic death at E11.5. CERT deficient embryos die from cardiac failure due to defective organogenesis, but not due to ceramide induced apoptotic or necrot...

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Detalles Bibliográficos
Autores principales: Rao, Raghavendra Pralhada, Scheffer, Luana, Srideshikan, Sargur M., Parthibane, Velayoudame, Kosakowska-Cholody, Teresa, Masood, M. Athar, Nagashima, Kunio, Gudla, Prabhakar, Lockett, Stephen, Acharya, Usha, Acharya, Jairaj K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958450/
https://www.ncbi.nlm.nih.gov/pubmed/24642596
http://dx.doi.org/10.1371/journal.pone.0092142

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