Drosophila USP5 Controls the Activation of Apoptosis and the Jun N-Terminal Kinase Pathway during Eye Development

The Jun N-terminal kinase pathway plays an important role in inducing programmed cell death (apoptosis) and is activated in a variety of contexts. The deubiquitinating enzymes (DUBs) are proteases regulating the protein stability by ubiquitin-proteasome system. Here, for the first time, we report th...

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Autores principales: Fan, Xiaolan, Huang, Qinzhu, Ye, Xiaolei, Lin, Yi, Chen, Yuting, Lin, Xinhua, Qu, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958489/
https://www.ncbi.nlm.nih.gov/pubmed/24643212
http://dx.doi.org/10.1371/journal.pone.0092250
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author Fan, Xiaolan
Huang, Qinzhu
Ye, Xiaolei
Lin, Yi
Chen, Yuting
Lin, Xinhua
Qu, Jia
author_facet Fan, Xiaolan
Huang, Qinzhu
Ye, Xiaolei
Lin, Yi
Chen, Yuting
Lin, Xinhua
Qu, Jia
author_sort Fan, Xiaolan
collection PubMed
description The Jun N-terminal kinase pathway plays an important role in inducing programmed cell death (apoptosis) and is activated in a variety of contexts. The deubiquitinating enzymes (DUBs) are proteases regulating the protein stability by ubiquitin-proteasome system. Here, for the first time, we report the phenotypes observed during eye development that are induced by deleting Drosophila USP5 gene, which encodes one of the USP subfamily of DUBs. usp5 mutants displayed defects in photoreceptor differentiation. Using genetic epistasis analysis and molecular markers, we show that most of these phenotypes are caused by the activation of apoptosis and JNK pathway. These data may provide a mechanistic model for understanding the mammalian usp5 gene.
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spelling pubmed-39584892014-03-24 Drosophila USP5 Controls the Activation of Apoptosis and the Jun N-Terminal Kinase Pathway during Eye Development Fan, Xiaolan Huang, Qinzhu Ye, Xiaolei Lin, Yi Chen, Yuting Lin, Xinhua Qu, Jia PLoS One Research Article The Jun N-terminal kinase pathway plays an important role in inducing programmed cell death (apoptosis) and is activated in a variety of contexts. The deubiquitinating enzymes (DUBs) are proteases regulating the protein stability by ubiquitin-proteasome system. Here, for the first time, we report the phenotypes observed during eye development that are induced by deleting Drosophila USP5 gene, which encodes one of the USP subfamily of DUBs. usp5 mutants displayed defects in photoreceptor differentiation. Using genetic epistasis analysis and molecular markers, we show that most of these phenotypes are caused by the activation of apoptosis and JNK pathway. These data may provide a mechanistic model for understanding the mammalian usp5 gene. Public Library of Science 2014-03-18 /pmc/articles/PMC3958489/ /pubmed/24643212 http://dx.doi.org/10.1371/journal.pone.0092250 Text en © 2014 Fan et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Fan, Xiaolan
Huang, Qinzhu
Ye, Xiaolei
Lin, Yi
Chen, Yuting
Lin, Xinhua
Qu, Jia
Drosophila USP5 Controls the Activation of Apoptosis and the Jun N-Terminal Kinase Pathway during Eye Development
title Drosophila USP5 Controls the Activation of Apoptosis and the Jun N-Terminal Kinase Pathway during Eye Development
title_full Drosophila USP5 Controls the Activation of Apoptosis and the Jun N-Terminal Kinase Pathway during Eye Development
title_fullStr Drosophila USP5 Controls the Activation of Apoptosis and the Jun N-Terminal Kinase Pathway during Eye Development
title_full_unstemmed Drosophila USP5 Controls the Activation of Apoptosis and the Jun N-Terminal Kinase Pathway during Eye Development
title_short Drosophila USP5 Controls the Activation of Apoptosis and the Jun N-Terminal Kinase Pathway during Eye Development
title_sort drosophila usp5 controls the activation of apoptosis and the jun n-terminal kinase pathway during eye development
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958489/
https://www.ncbi.nlm.nih.gov/pubmed/24643212
http://dx.doi.org/10.1371/journal.pone.0092250
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