Pharmacological Inhibition of TPL2/MAP3K8 Blocks Human Cytotoxic T Lymphocyte Effector Functions

CD8(+) cytotoxic T lymphocytes (CTLs) play a major role in defense against intracellular pathogens. During development, antigen-presenting cells secrete innate cytokines such as IL-12 and IFN-α, which drive CTL differentiation into diverse populations of effector and long-lived memory cells. Using w...

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Detalles Bibliográficos
Autores principales: Chowdhury, Fatema Z., Estrada, Leonardo D., Murray, Sean, Forman, James, Farrar, J. David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958505/
https://www.ncbi.nlm.nih.gov/pubmed/24642963
http://dx.doi.org/10.1371/journal.pone.0092187

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