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Multimodal Effects of Small Molecule ROCK and LIMK Inhibitors on Mitosis, and Their Implication as Anti-Leukemia Agents

Accurate chromosome segregation is vital for cell viability. Many cancer cells show chromosome instability (CIN) due to aberrant expression of the genes involved in chromosome segregation. The induction of massive chromosome segregation errors in such cancer cells by small molecule inhibitors is an...

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Detalles Bibliográficos
Autores principales:	Oku, Yusuke, Tareyanagi, Chiaki, Takaya, Shinichi, Osaka, Sayaka, Ujiie, Haruki, Yoshida, Kentaro, Nishiya, Naoyuki, Uehara, Yoshimasa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958508/ https://www.ncbi.nlm.nih.gov/pubmed/24642638 http://dx.doi.org/10.1371/journal.pone.0092402

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