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Early MEK1/2 Inhibition after Global Cerebral Ischemia in Rats Reduces Brain Damage and Improves Outcome by Preventing Delayed Vasoconstrictor Receptor Upregulation

BACKGROUND: Global cerebral ischemia following cardiac arrest is associated with increased cerebral vasoconstriction and decreased cerebral blood flow, contributing to delayed neuronal cell death and neurological detriments in affected patients. We hypothesize that upregulation of contractile ET(B)...

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Detalles Bibliográficos
Autores principales:	Johansson, Sara Ellinor, Larsen, Stine Schmidt, Povlsen, Gro Klitgaard, Edvinsson, Lars
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958517/ https://www.ncbi.nlm.nih.gov/pubmed/24642693 http://dx.doi.org/10.1371/journal.pone.0092417

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