Mesenchymal Stem Cells Do Not Prevent Antibody Responses against Human α-L-Iduronidase when Used to Treat Mucopolysaccharidosis Type I

Mucopolysaccharidosis type I (MPSI) is an autosomal recessive disease that leads to systemic lysosomal storage, which is caused by the absence of α-L-iduronidase (IDUA). Enzyme replacement therapy is recognized as the best therapeutic option for MPSI; however, high titers of anti-IDUA antibody have...

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Detalles Bibliográficos
Autores principales: Martin, Priscila Keiko Matsumoto, Stilhano, Roberta Sessa, Samoto, Vivian Yochiko, Takiya, Christina Maeda, Peres, Giovani Bravin, da Silva Michelacci, Yara Maria Correa, da Silva, Flavia Helena, Pereira, Vanessa Gonçalves, D'Almeida, Vânia, Marques, Fabio Luiz Navarro, Otake, Andreia Hanada, Chammas, Roger, Han, Sang Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958533/
https://www.ncbi.nlm.nih.gov/pubmed/24642723
http://dx.doi.org/10.1371/journal.pone.0092420

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