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Molecular Evolution of the Vertebrate FK506 Binding Protein 25

FK506 binding proteins (FKBPs) belong to immunophilins with peptidyl-prolyl isomerases (PPIases) activity. FKBP25 (also known as FKBP3) is one of the nuclear DNA-binding proteins in the FKBPs family, which plays an important role in regulating transcription and chromatin structure. The calculation o...

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Autores principales: Liu, Fei, Wei, Xiao-Long, Li, Hao, Wei, Ji-Fu, Wang, Yong-Qing, Gong, Xiao-Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958658/
https://www.ncbi.nlm.nih.gov/pubmed/24724077
http://dx.doi.org/10.1155/2014/402603
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author Liu, Fei
Wei, Xiao-Long
Li, Hao
Wei, Ji-Fu
Wang, Yong-Qing
Gong, Xiao-Jian
author_facet Liu, Fei
Wei, Xiao-Long
Li, Hao
Wei, Ji-Fu
Wang, Yong-Qing
Gong, Xiao-Jian
author_sort Liu, Fei
collection PubMed
description FK506 binding proteins (FKBPs) belong to immunophilins with peptidyl-prolyl isomerases (PPIases) activity. FKBP25 (also known as FKBP3) is one of the nuclear DNA-binding proteins in the FKBPs family, which plays an important role in regulating transcription and chromatin structure. The calculation of nonsynonymous and synonymous substitution rates suggested that FKBP25 undergoes purifying selection throughout the whole vertebrate evolution. Moreover, the result of site-specific tests showed that no sites were detected under positive selection. Only one PPIase domain was detected by searching FKBP25 sequences at Pfam and SMART domain databases. Mammalian FKBP25 possess exon-intron conservation, although conservation in the whole vertebrate lineage is incomplete. The result of this study suggests that the purifying selection triggers FKBP25 evolutionary history, which allows us to discover the complete role of the PPIase domain in the interaction between FKBP25 and nuclear proteins. Moreover, intron alterations during FKBP25 evolution that regulate gene splicing may be involved in the purifying selection.
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spelling pubmed-39586582014-04-10 Molecular Evolution of the Vertebrate FK506 Binding Protein 25 Liu, Fei Wei, Xiao-Long Li, Hao Wei, Ji-Fu Wang, Yong-Qing Gong, Xiao-Jian Int J Genomics Research Article FK506 binding proteins (FKBPs) belong to immunophilins with peptidyl-prolyl isomerases (PPIases) activity. FKBP25 (also known as FKBP3) is one of the nuclear DNA-binding proteins in the FKBPs family, which plays an important role in regulating transcription and chromatin structure. The calculation of nonsynonymous and synonymous substitution rates suggested that FKBP25 undergoes purifying selection throughout the whole vertebrate evolution. Moreover, the result of site-specific tests showed that no sites were detected under positive selection. Only one PPIase domain was detected by searching FKBP25 sequences at Pfam and SMART domain databases. Mammalian FKBP25 possess exon-intron conservation, although conservation in the whole vertebrate lineage is incomplete. The result of this study suggests that the purifying selection triggers FKBP25 evolutionary history, which allows us to discover the complete role of the PPIase domain in the interaction between FKBP25 and nuclear proteins. Moreover, intron alterations during FKBP25 evolution that regulate gene splicing may be involved in the purifying selection. Hindawi Publishing Corporation 2014 2014-03-02 /pmc/articles/PMC3958658/ /pubmed/24724077 http://dx.doi.org/10.1155/2014/402603 Text en Copyright © 2014 Fei Liu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Liu, Fei
Wei, Xiao-Long
Li, Hao
Wei, Ji-Fu
Wang, Yong-Qing
Gong, Xiao-Jian
Molecular Evolution of the Vertebrate FK506 Binding Protein 25
title Molecular Evolution of the Vertebrate FK506 Binding Protein 25
title_full Molecular Evolution of the Vertebrate FK506 Binding Protein 25
title_fullStr Molecular Evolution of the Vertebrate FK506 Binding Protein 25
title_full_unstemmed Molecular Evolution of the Vertebrate FK506 Binding Protein 25
title_short Molecular Evolution of the Vertebrate FK506 Binding Protein 25
title_sort molecular evolution of the vertebrate fk506 binding protein 25
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958658/
https://www.ncbi.nlm.nih.gov/pubmed/24724077
http://dx.doi.org/10.1155/2014/402603
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