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Early Left Ventricular Systolic and Diastolic Dysfunction in Patients with Newly Diagnosed Obstructive Sleep Apnoea and Normal Left Ventricular Ejection Fraction
The aim of the study was to evaluate whether obstructive sleep apnea (OSA) contributes directly to left ventricular (LV) diastolic and regional systolic dysfunction in newly diagnosed OSA with normal left ventricle ejection fraction. Methods. 125 consecutive patients were prospectively enrolled in t...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958663/ https://www.ncbi.nlm.nih.gov/pubmed/24723836 http://dx.doi.org/10.1155/2014/898746 |
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author | Danica, Lisulov Popovic Krotin, Mirjana Zdravkovic, Marija Soldatovic, Ivan Zdravkovic, Darko Brajkovic, Milica Gardijan, Vera Saric, Jelena Pokrajac, Ruzica Lovic, Dragan Stevanovic, Predrag Gajic, Milina Tancic Vukcevic, Miodrag |
author_facet | Danica, Lisulov Popovic Krotin, Mirjana Zdravkovic, Marija Soldatovic, Ivan Zdravkovic, Darko Brajkovic, Milica Gardijan, Vera Saric, Jelena Pokrajac, Ruzica Lovic, Dragan Stevanovic, Predrag Gajic, Milina Tancic Vukcevic, Miodrag |
author_sort | Danica, Lisulov Popovic |
collection | PubMed |
description | The aim of the study was to evaluate whether obstructive sleep apnea (OSA) contributes directly to left ventricular (LV) diastolic and regional systolic dysfunction in newly diagnosed OSA with normal left ventricle ejection fraction. Methods. 125 consecutive patients were prospectively enrolled in the study. Control group consisted of 78 asymptomatic age-matched healthy subjects who did not have any cardiovascular and respiratory diseases. All patients had undergone overnight polysomnography and standard transthoracic and tissue Doppler imaging echocardiogram. Results. The E/A ratio and the peak E wave at mitral flow were significantly lower and the peak A wave at mitral flow was significantly higher in OSA patients compared with control subjects. Left ventricle isovolumetric relaxation time (IVRT) and mitral valve flow propagation (MVFP) were significantly longer in OSA patients than in controls. Tissue Doppler derived S′ amplitude of lateral part at mitral valve (S′Lm) and E′ wave amplitudes both at the lateral (E′Lm) and septal parts of the mitral valve (E′Sm) were significantly lower in OSA patients compared to controls. Conclusion. Newly diagnosed OSA patients with normal global LV function have significantly impaired diastolic function and regional longitudinal systolic function. OSA is independently associated with these changes in LV function. |
format | Online Article Text |
id | pubmed-3958663 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39586632014-04-10 Early Left Ventricular Systolic and Diastolic Dysfunction in Patients with Newly Diagnosed Obstructive Sleep Apnoea and Normal Left Ventricular Ejection Fraction Danica, Lisulov Popovic Krotin, Mirjana Zdravkovic, Marija Soldatovic, Ivan Zdravkovic, Darko Brajkovic, Milica Gardijan, Vera Saric, Jelena Pokrajac, Ruzica Lovic, Dragan Stevanovic, Predrag Gajic, Milina Tancic Vukcevic, Miodrag ScientificWorldJournal Research Article The aim of the study was to evaluate whether obstructive sleep apnea (OSA) contributes directly to left ventricular (LV) diastolic and regional systolic dysfunction in newly diagnosed OSA with normal left ventricle ejection fraction. Methods. 125 consecutive patients were prospectively enrolled in the study. Control group consisted of 78 asymptomatic age-matched healthy subjects who did not have any cardiovascular and respiratory diseases. All patients had undergone overnight polysomnography and standard transthoracic and tissue Doppler imaging echocardiogram. Results. The E/A ratio and the peak E wave at mitral flow were significantly lower and the peak A wave at mitral flow was significantly higher in OSA patients compared with control subjects. Left ventricle isovolumetric relaxation time (IVRT) and mitral valve flow propagation (MVFP) were significantly longer in OSA patients than in controls. Tissue Doppler derived S′ amplitude of lateral part at mitral valve (S′Lm) and E′ wave amplitudes both at the lateral (E′Lm) and septal parts of the mitral valve (E′Sm) were significantly lower in OSA patients compared to controls. Conclusion. Newly diagnosed OSA patients with normal global LV function have significantly impaired diastolic function and regional longitudinal systolic function. OSA is independently associated with these changes in LV function. Hindawi Publishing Corporation 2014-02-27 /pmc/articles/PMC3958663/ /pubmed/24723836 http://dx.doi.org/10.1155/2014/898746 Text en Copyright © 2014 Lisulov Popovic Danica et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Danica, Lisulov Popovic Krotin, Mirjana Zdravkovic, Marija Soldatovic, Ivan Zdravkovic, Darko Brajkovic, Milica Gardijan, Vera Saric, Jelena Pokrajac, Ruzica Lovic, Dragan Stevanovic, Predrag Gajic, Milina Tancic Vukcevic, Miodrag Early Left Ventricular Systolic and Diastolic Dysfunction in Patients with Newly Diagnosed Obstructive Sleep Apnoea and Normal Left Ventricular Ejection Fraction |
title | Early Left Ventricular Systolic and Diastolic Dysfunction in Patients with Newly Diagnosed Obstructive Sleep Apnoea and Normal Left Ventricular Ejection Fraction |
title_full | Early Left Ventricular Systolic and Diastolic Dysfunction in Patients with Newly Diagnosed Obstructive Sleep Apnoea and Normal Left Ventricular Ejection Fraction |
title_fullStr | Early Left Ventricular Systolic and Diastolic Dysfunction in Patients with Newly Diagnosed Obstructive Sleep Apnoea and Normal Left Ventricular Ejection Fraction |
title_full_unstemmed | Early Left Ventricular Systolic and Diastolic Dysfunction in Patients with Newly Diagnosed Obstructive Sleep Apnoea and Normal Left Ventricular Ejection Fraction |
title_short | Early Left Ventricular Systolic and Diastolic Dysfunction in Patients with Newly Diagnosed Obstructive Sleep Apnoea and Normal Left Ventricular Ejection Fraction |
title_sort | early left ventricular systolic and diastolic dysfunction in patients with newly diagnosed obstructive sleep apnoea and normal left ventricular ejection fraction |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958663/ https://www.ncbi.nlm.nih.gov/pubmed/24723836 http://dx.doi.org/10.1155/2014/898746 |
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