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Thioredoxin System Regulation in the Central Nervous System: Experimental Models and Clinical Evidence

The reactive oxygen species produced continuously during oxidative metabolism are generated at very high rates in the brain. Therefore, defending against oxidative stress is an essential task within the brain. An important cellular system against oxidative stress is the thioredoxin system (TS). TS i...

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Detalles Bibliográficos
Autores principales: Silva-Adaya, Daniela, Gonsebatt, María E., Guevara, Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958682/
https://www.ncbi.nlm.nih.gov/pubmed/24723994
http://dx.doi.org/10.1155/2014/590808
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author Silva-Adaya, Daniela
Gonsebatt, María E.
Guevara, Jorge
author_facet Silva-Adaya, Daniela
Gonsebatt, María E.
Guevara, Jorge
author_sort Silva-Adaya, Daniela
collection PubMed
description The reactive oxygen species produced continuously during oxidative metabolism are generated at very high rates in the brain. Therefore, defending against oxidative stress is an essential task within the brain. An important cellular system against oxidative stress is the thioredoxin system (TS). TS is composed of thioredoxin, thioredoxin reductase, and NADPH. This review focuses on the evidence gathered in recent investigations into the central nervous system, specifically the different brain regions in which the TS is expressed. Furthermore, we address the conditions that modulate the thioredoxin system in both, animal models and the postmortem brains of human patients associated with the most common neurodegenerative disorders, in which the thioredoxin system could play an important part.
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spelling pubmed-39586822014-04-10 Thioredoxin System Regulation in the Central Nervous System: Experimental Models and Clinical Evidence Silva-Adaya, Daniela Gonsebatt, María E. Guevara, Jorge Oxid Med Cell Longev Review Article The reactive oxygen species produced continuously during oxidative metabolism are generated at very high rates in the brain. Therefore, defending against oxidative stress is an essential task within the brain. An important cellular system against oxidative stress is the thioredoxin system (TS). TS is composed of thioredoxin, thioredoxin reductase, and NADPH. This review focuses on the evidence gathered in recent investigations into the central nervous system, specifically the different brain regions in which the TS is expressed. Furthermore, we address the conditions that modulate the thioredoxin system in both, animal models and the postmortem brains of human patients associated with the most common neurodegenerative disorders, in which the thioredoxin system could play an important part. Hindawi Publishing Corporation 2014 2014-02-27 /pmc/articles/PMC3958682/ /pubmed/24723994 http://dx.doi.org/10.1155/2014/590808 Text en Copyright © 2014 Daniela Silva-Adaya et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Silva-Adaya, Daniela
Gonsebatt, María E.
Guevara, Jorge
Thioredoxin System Regulation in the Central Nervous System: Experimental Models and Clinical Evidence
title Thioredoxin System Regulation in the Central Nervous System: Experimental Models and Clinical Evidence
title_full Thioredoxin System Regulation in the Central Nervous System: Experimental Models and Clinical Evidence
title_fullStr Thioredoxin System Regulation in the Central Nervous System: Experimental Models and Clinical Evidence
title_full_unstemmed Thioredoxin System Regulation in the Central Nervous System: Experimental Models and Clinical Evidence
title_short Thioredoxin System Regulation in the Central Nervous System: Experimental Models and Clinical Evidence
title_sort thioredoxin system regulation in the central nervous system: experimental models and clinical evidence
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958682/
https://www.ncbi.nlm.nih.gov/pubmed/24723994
http://dx.doi.org/10.1155/2014/590808
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