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Seminal Plasma Initiates a Neisseria gonorrhoeae Transmission State
Niche-restricted pathogens are evolutionarily linked with the specific biological fluids that are encountered during infection. Neisseria gonorrhoeae causes the genital infection gonorrhea and is exposed to seminal fluid during sexual transmission. Treatment of N. gonorrhoeae with seminal plasma or...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Microbiology
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958800/ https://www.ncbi.nlm.nih.gov/pubmed/24595372 http://dx.doi.org/10.1128/mBio.01004-13 |
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author | Anderson, Mark T. Dewenter, Lena Maier, Berenike Seifert, H. Steven |
author_facet | Anderson, Mark T. Dewenter, Lena Maier, Berenike Seifert, H. Steven |
author_sort | Anderson, Mark T. |
collection | PubMed |
description | Niche-restricted pathogens are evolutionarily linked with the specific biological fluids that are encountered during infection. Neisseria gonorrhoeae causes the genital infection gonorrhea and is exposed to seminal fluid during sexual transmission. Treatment of N. gonorrhoeae with seminal plasma or purified semen proteins lactoferrin, serum albumin, and prostate-specific antigen each facilitated type IV pilus-mediated twitching motility of the bacterium. Motility in the presence of seminal plasma was characterized by high velocity and low directional persistence. In addition, infection of epithelial cells with N. gonorrhoeae in the presence of seminal plasma resulted in enhanced microcolony formation. Close association of multiple pili in the form of bundles was also disrupted after seminal plasma treatment leading to an increase in the number of single pilus filaments on the bacterial surface. Thus, exposure of N. gonorrhoeae to seminal plasma is proposed to alter bacterial motility and aggregation characteristics to influence the processes of transmission and colonization. |
format | Online Article Text |
id | pubmed-3958800 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | American Society of Microbiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-39588002014-03-27 Seminal Plasma Initiates a Neisseria gonorrhoeae Transmission State Anderson, Mark T. Dewenter, Lena Maier, Berenike Seifert, H. Steven mBio Research Article Niche-restricted pathogens are evolutionarily linked with the specific biological fluids that are encountered during infection. Neisseria gonorrhoeae causes the genital infection gonorrhea and is exposed to seminal fluid during sexual transmission. Treatment of N. gonorrhoeae with seminal plasma or purified semen proteins lactoferrin, serum albumin, and prostate-specific antigen each facilitated type IV pilus-mediated twitching motility of the bacterium. Motility in the presence of seminal plasma was characterized by high velocity and low directional persistence. In addition, infection of epithelial cells with N. gonorrhoeae in the presence of seminal plasma resulted in enhanced microcolony formation. Close association of multiple pili in the form of bundles was also disrupted after seminal plasma treatment leading to an increase in the number of single pilus filaments on the bacterial surface. Thus, exposure of N. gonorrhoeae to seminal plasma is proposed to alter bacterial motility and aggregation characteristics to influence the processes of transmission and colonization. American Society of Microbiology 2014-03-04 /pmc/articles/PMC3958800/ /pubmed/24595372 http://dx.doi.org/10.1128/mBio.01004-13 Text en Copyright © 2014 Anderson et al. http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license (http://creativecommons.org/licenses/by-nc-sa/3.0/) , which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Anderson, Mark T. Dewenter, Lena Maier, Berenike Seifert, H. Steven Seminal Plasma Initiates a Neisseria gonorrhoeae Transmission State |
title | Seminal Plasma Initiates a Neisseria gonorrhoeae Transmission State |
title_full | Seminal Plasma Initiates a Neisseria gonorrhoeae Transmission State |
title_fullStr | Seminal Plasma Initiates a Neisseria gonorrhoeae Transmission State |
title_full_unstemmed | Seminal Plasma Initiates a Neisseria gonorrhoeae Transmission State |
title_short | Seminal Plasma Initiates a Neisseria gonorrhoeae Transmission State |
title_sort | seminal plasma initiates a neisseria gonorrhoeae transmission state |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958800/ https://www.ncbi.nlm.nih.gov/pubmed/24595372 http://dx.doi.org/10.1128/mBio.01004-13 |
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