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Involvement of Oxidative Stress and Inflammation in Liver Injury Caused by Perfluorooctanoic Acid Exposure in Mice
Perfluorooctanoic acid (PFOA) is widely present in the environment and has been reported to induce hepatic toxicity in animals and humans. In this study, mice were orally administered different concentrations of PFOA (2.5, 5, or 10 mg/kg/day). Histological examination showed that the exposure to PFO...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958804/ https://www.ncbi.nlm.nih.gov/pubmed/24724082 http://dx.doi.org/10.1155/2014/409837 |
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author | Yang, Bei Zou, Weiying Hu, Zhenzhen Liu, Fangming Zhou, Ling Yang, Shulong Kuang, Haibin Wu, Lei Wei, Jie Wang, Jinglei Zou, Ting Zhang, Dalei |
author_facet | Yang, Bei Zou, Weiying Hu, Zhenzhen Liu, Fangming Zhou, Ling Yang, Shulong Kuang, Haibin Wu, Lei Wei, Jie Wang, Jinglei Zou, Ting Zhang, Dalei |
author_sort | Yang, Bei |
collection | PubMed |
description | Perfluorooctanoic acid (PFOA) is widely present in the environment and has been reported to induce hepatic toxicity in animals and humans. In this study, mice were orally administered different concentrations of PFOA (2.5, 5, or 10 mg/kg/day). Histological examination showed that the exposure to PFOA for 14 consecutive days led to serious hepatocellular injury and obvious inflammatory cell infiltration. In addition, malondialdehyde formation and hydrogen peroxide generation, indicators of oxidative stress, were significantly induced by PFOA treatment in the liver of mice. Furthermore, hepatic levels of interleukin-6, cyclooxygenase-2, and C-reactive protein, markers of inflammatory response, were markedly increased by exposure to PFOA in mice. These results demonstrated that PFOA-induced hepatic toxicity may be involved in oxidative stress and inflammatory response in mice. |
format | Online Article Text |
id | pubmed-3958804 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39588042014-04-10 Involvement of Oxidative Stress and Inflammation in Liver Injury Caused by Perfluorooctanoic Acid Exposure in Mice Yang, Bei Zou, Weiying Hu, Zhenzhen Liu, Fangming Zhou, Ling Yang, Shulong Kuang, Haibin Wu, Lei Wei, Jie Wang, Jinglei Zou, Ting Zhang, Dalei Biomed Res Int Research Article Perfluorooctanoic acid (PFOA) is widely present in the environment and has been reported to induce hepatic toxicity in animals and humans. In this study, mice were orally administered different concentrations of PFOA (2.5, 5, or 10 mg/kg/day). Histological examination showed that the exposure to PFOA for 14 consecutive days led to serious hepatocellular injury and obvious inflammatory cell infiltration. In addition, malondialdehyde formation and hydrogen peroxide generation, indicators of oxidative stress, were significantly induced by PFOA treatment in the liver of mice. Furthermore, hepatic levels of interleukin-6, cyclooxygenase-2, and C-reactive protein, markers of inflammatory response, were markedly increased by exposure to PFOA in mice. These results demonstrated that PFOA-induced hepatic toxicity may be involved in oxidative stress and inflammatory response in mice. Hindawi Publishing Corporation 2014 2014-03-02 /pmc/articles/PMC3958804/ /pubmed/24724082 http://dx.doi.org/10.1155/2014/409837 Text en Copyright © 2014 Bei Yang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Yang, Bei Zou, Weiying Hu, Zhenzhen Liu, Fangming Zhou, Ling Yang, Shulong Kuang, Haibin Wu, Lei Wei, Jie Wang, Jinglei Zou, Ting Zhang, Dalei Involvement of Oxidative Stress and Inflammation in Liver Injury Caused by Perfluorooctanoic Acid Exposure in Mice |
title | Involvement of Oxidative Stress and Inflammation in Liver Injury Caused by Perfluorooctanoic Acid Exposure in Mice |
title_full | Involvement of Oxidative Stress and Inflammation in Liver Injury Caused by Perfluorooctanoic Acid Exposure in Mice |
title_fullStr | Involvement of Oxidative Stress and Inflammation in Liver Injury Caused by Perfluorooctanoic Acid Exposure in Mice |
title_full_unstemmed | Involvement of Oxidative Stress and Inflammation in Liver Injury Caused by Perfluorooctanoic Acid Exposure in Mice |
title_short | Involvement of Oxidative Stress and Inflammation in Liver Injury Caused by Perfluorooctanoic Acid Exposure in Mice |
title_sort | involvement of oxidative stress and inflammation in liver injury caused by perfluorooctanoic acid exposure in mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958804/ https://www.ncbi.nlm.nih.gov/pubmed/24724082 http://dx.doi.org/10.1155/2014/409837 |
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