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Involvement of Oxidative Stress and Inflammation in Liver Injury Caused by Perfluorooctanoic Acid Exposure in Mice

Perfluorooctanoic acid (PFOA) is widely present in the environment and has been reported to induce hepatic toxicity in animals and humans. In this study, mice were orally administered different concentrations of PFOA (2.5, 5, or 10 mg/kg/day). Histological examination showed that the exposure to PFO...

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Autores principales: Yang, Bei, Zou, Weiying, Hu, Zhenzhen, Liu, Fangming, Zhou, Ling, Yang, Shulong, Kuang, Haibin, Wu, Lei, Wei, Jie, Wang, Jinglei, Zou, Ting, Zhang, Dalei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958804/
https://www.ncbi.nlm.nih.gov/pubmed/24724082
http://dx.doi.org/10.1155/2014/409837
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author Yang, Bei
Zou, Weiying
Hu, Zhenzhen
Liu, Fangming
Zhou, Ling
Yang, Shulong
Kuang, Haibin
Wu, Lei
Wei, Jie
Wang, Jinglei
Zou, Ting
Zhang, Dalei
author_facet Yang, Bei
Zou, Weiying
Hu, Zhenzhen
Liu, Fangming
Zhou, Ling
Yang, Shulong
Kuang, Haibin
Wu, Lei
Wei, Jie
Wang, Jinglei
Zou, Ting
Zhang, Dalei
author_sort Yang, Bei
collection PubMed
description Perfluorooctanoic acid (PFOA) is widely present in the environment and has been reported to induce hepatic toxicity in animals and humans. In this study, mice were orally administered different concentrations of PFOA (2.5, 5, or 10 mg/kg/day). Histological examination showed that the exposure to PFOA for 14 consecutive days led to serious hepatocellular injury and obvious inflammatory cell infiltration. In addition, malondialdehyde formation and hydrogen peroxide generation, indicators of oxidative stress, were significantly induced by PFOA treatment in the liver of mice. Furthermore, hepatic levels of interleukin-6, cyclooxygenase-2, and C-reactive protein, markers of inflammatory response, were markedly increased by exposure to PFOA in mice. These results demonstrated that PFOA-induced hepatic toxicity may be involved in oxidative stress and inflammatory response in mice.
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spelling pubmed-39588042014-04-10 Involvement of Oxidative Stress and Inflammation in Liver Injury Caused by Perfluorooctanoic Acid Exposure in Mice Yang, Bei Zou, Weiying Hu, Zhenzhen Liu, Fangming Zhou, Ling Yang, Shulong Kuang, Haibin Wu, Lei Wei, Jie Wang, Jinglei Zou, Ting Zhang, Dalei Biomed Res Int Research Article Perfluorooctanoic acid (PFOA) is widely present in the environment and has been reported to induce hepatic toxicity in animals and humans. In this study, mice were orally administered different concentrations of PFOA (2.5, 5, or 10 mg/kg/day). Histological examination showed that the exposure to PFOA for 14 consecutive days led to serious hepatocellular injury and obvious inflammatory cell infiltration. In addition, malondialdehyde formation and hydrogen peroxide generation, indicators of oxidative stress, were significantly induced by PFOA treatment in the liver of mice. Furthermore, hepatic levels of interleukin-6, cyclooxygenase-2, and C-reactive protein, markers of inflammatory response, were markedly increased by exposure to PFOA in mice. These results demonstrated that PFOA-induced hepatic toxicity may be involved in oxidative stress and inflammatory response in mice. Hindawi Publishing Corporation 2014 2014-03-02 /pmc/articles/PMC3958804/ /pubmed/24724082 http://dx.doi.org/10.1155/2014/409837 Text en Copyright © 2014 Bei Yang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yang, Bei
Zou, Weiying
Hu, Zhenzhen
Liu, Fangming
Zhou, Ling
Yang, Shulong
Kuang, Haibin
Wu, Lei
Wei, Jie
Wang, Jinglei
Zou, Ting
Zhang, Dalei
Involvement of Oxidative Stress and Inflammation in Liver Injury Caused by Perfluorooctanoic Acid Exposure in Mice
title Involvement of Oxidative Stress and Inflammation in Liver Injury Caused by Perfluorooctanoic Acid Exposure in Mice
title_full Involvement of Oxidative Stress and Inflammation in Liver Injury Caused by Perfluorooctanoic Acid Exposure in Mice
title_fullStr Involvement of Oxidative Stress and Inflammation in Liver Injury Caused by Perfluorooctanoic Acid Exposure in Mice
title_full_unstemmed Involvement of Oxidative Stress and Inflammation in Liver Injury Caused by Perfluorooctanoic Acid Exposure in Mice
title_short Involvement of Oxidative Stress and Inflammation in Liver Injury Caused by Perfluorooctanoic Acid Exposure in Mice
title_sort involvement of oxidative stress and inflammation in liver injury caused by perfluorooctanoic acid exposure in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958804/
https://www.ncbi.nlm.nih.gov/pubmed/24724082
http://dx.doi.org/10.1155/2014/409837
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