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Elevated Th22 Cells Correlated with Th17 Cells in Peripheral Blood of Patients with Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a hematological tumor in which progress T helper (Th) subsets including Th22, Th17, and Th1 cells play a pivotal role. However, the role of T helper (Th) subsets in the immune pathogenesis of AML remains unclear. Here, we investigated frequencies of Th22, Th17, pure T...

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Autores principales: Yu, Shuang, Liu, Chuanfang, Zhang, Lei, Shan, Baozhong, Tian, Tian, Hu, Yu, Shao, Linlin, Sun, Yuanxin, Ji, Chunyan, Ma, Daoxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958830/
https://www.ncbi.nlm.nih.gov/pubmed/24473142
http://dx.doi.org/10.3390/ijms15021927
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author Yu, Shuang
Liu, Chuanfang
Zhang, Lei
Shan, Baozhong
Tian, Tian
Hu, Yu
Shao, Linlin
Sun, Yuanxin
Ji, Chunyan
Ma, Daoxin
author_facet Yu, Shuang
Liu, Chuanfang
Zhang, Lei
Shan, Baozhong
Tian, Tian
Hu, Yu
Shao, Linlin
Sun, Yuanxin
Ji, Chunyan
Ma, Daoxin
author_sort Yu, Shuang
collection PubMed
description Acute myeloid leukemia (AML) is a hematological tumor in which progress T helper (Th) subsets including Th22, Th17, and Th1 cells play a pivotal role. However, the role of T helper (Th) subsets in the immune pathogenesis of AML remains unclear. Here, we investigated frequencies of Th22, Th17, pure Th17, and Th1 cells in the peripheral blood (PB) of AML patients. We demonstrated that Th22, Th17, and pure Th17 in newly-diagnosed (ND) and non-complete remission (Non-CR) AML patients and plasma IL-22 in ND AML patients were significantly increased. Retinoid-related orphan receptor C (RORC) expression was significantly elevated in CR and Non-CR AML patients. However, Th1 in ND AML patients and IL-17 in ND, Non-CR or CR AML patients was significantly decreased compared with controls. Moreover, Th22 and IL-22 showed positive correlation with pure Th17, but Th22 showed negative correlation with Th1 in ND AML patients. RORC showed positive correlation with Th22 and approximately positive correlation with pure Th17 in Non-CR patients. PB blast cell showed positive correlation with Th22 and negative correlation with Th1 in ND AML patients. Our results indicate that Th22 and pure Th17 cells conjointly contribute to the pathogenesis of AML and might be promising novel clinical index for AML.
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spelling pubmed-39588302014-03-20 Elevated Th22 Cells Correlated with Th17 Cells in Peripheral Blood of Patients with Acute Myeloid Leukemia Yu, Shuang Liu, Chuanfang Zhang, Lei Shan, Baozhong Tian, Tian Hu, Yu Shao, Linlin Sun, Yuanxin Ji, Chunyan Ma, Daoxin Int J Mol Sci Article Acute myeloid leukemia (AML) is a hematological tumor in which progress T helper (Th) subsets including Th22, Th17, and Th1 cells play a pivotal role. However, the role of T helper (Th) subsets in the immune pathogenesis of AML remains unclear. Here, we investigated frequencies of Th22, Th17, pure Th17, and Th1 cells in the peripheral blood (PB) of AML patients. We demonstrated that Th22, Th17, and pure Th17 in newly-diagnosed (ND) and non-complete remission (Non-CR) AML patients and plasma IL-22 in ND AML patients were significantly increased. Retinoid-related orphan receptor C (RORC) expression was significantly elevated in CR and Non-CR AML patients. However, Th1 in ND AML patients and IL-17 in ND, Non-CR or CR AML patients was significantly decreased compared with controls. Moreover, Th22 and IL-22 showed positive correlation with pure Th17, but Th22 showed negative correlation with Th1 in ND AML patients. RORC showed positive correlation with Th22 and approximately positive correlation with pure Th17 in Non-CR patients. PB blast cell showed positive correlation with Th22 and negative correlation with Th1 in ND AML patients. Our results indicate that Th22 and pure Th17 cells conjointly contribute to the pathogenesis of AML and might be promising novel clinical index for AML. Molecular Diversity Preservation International (MDPI) 2014-01-27 /pmc/articles/PMC3958830/ /pubmed/24473142 http://dx.doi.org/10.3390/ijms15021927 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Yu, Shuang
Liu, Chuanfang
Zhang, Lei
Shan, Baozhong
Tian, Tian
Hu, Yu
Shao, Linlin
Sun, Yuanxin
Ji, Chunyan
Ma, Daoxin
Elevated Th22 Cells Correlated with Th17 Cells in Peripheral Blood of Patients with Acute Myeloid Leukemia
title Elevated Th22 Cells Correlated with Th17 Cells in Peripheral Blood of Patients with Acute Myeloid Leukemia
title_full Elevated Th22 Cells Correlated with Th17 Cells in Peripheral Blood of Patients with Acute Myeloid Leukemia
title_fullStr Elevated Th22 Cells Correlated with Th17 Cells in Peripheral Blood of Patients with Acute Myeloid Leukemia
title_full_unstemmed Elevated Th22 Cells Correlated with Th17 Cells in Peripheral Blood of Patients with Acute Myeloid Leukemia
title_short Elevated Th22 Cells Correlated with Th17 Cells in Peripheral Blood of Patients with Acute Myeloid Leukemia
title_sort elevated th22 cells correlated with th17 cells in peripheral blood of patients with acute myeloid leukemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958830/
https://www.ncbi.nlm.nih.gov/pubmed/24473142
http://dx.doi.org/10.3390/ijms15021927
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