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Role of mtDNA Haplogroups in the Prevalence of Knee Osteoarthritis in a Southern Chinese Population

Mitochondrial DNA (mtDNA) has been implicated in various human degenerative diseases. However, the role of mtDNA in Osteoarthritis (OA) is less known. To investigate whether mtDNA haplogroups contribute to the prevalence of knee OA, we have carried out a comprehensive case-control study on 187 knee...

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Autores principales: Fang, Hezhi, Liu, Xinwei, Shen, Lijun, Li, Fengjie, Liu, Yihong, Chi, Hongbo, Miao, Huikai, Lu, Jianxin, Bai, Yidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958873/
https://www.ncbi.nlm.nih.gov/pubmed/24534808
http://dx.doi.org/10.3390/ijms15022646
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author Fang, Hezhi
Liu, Xinwei
Shen, Lijun
Li, Fengjie
Liu, Yihong
Chi, Hongbo
Miao, Huikai
Lu, Jianxin
Bai, Yidong
author_facet Fang, Hezhi
Liu, Xinwei
Shen, Lijun
Li, Fengjie
Liu, Yihong
Chi, Hongbo
Miao, Huikai
Lu, Jianxin
Bai, Yidong
author_sort Fang, Hezhi
collection PubMed
description Mitochondrial DNA (mtDNA) has been implicated in various human degenerative diseases. However, the role of mtDNA in Osteoarthritis (OA) is less known. To investigate whether mtDNA haplogroups contribute to the prevalence of knee OA, we have carried out a comprehensive case-control study on 187 knee OA patients and 420 geographically matched controls in southern China. OA patients were classified on the Kellgren/Lawrence scale from two to four for the disease severity study and the data were analyzed by adjusting for age and sex. We found that patients with haplogroup G (OR = 3.834; 95% CI 1.139, 12.908; p = 0.03) and T16362C (OR = 1.715; 95% CI 1.174, 2.506; p = 0.005) exhibited an increased risk of OA occurrence. Furthermore, patients carrying haplogroup G had a higher severity progression of knee OA (OR = 10.870; 95% CI 1.307, 90.909; p = 0.007). On the other hand, people with haplogroup B/B4 (OR = 0.503; 95% CI 0.283, 0.893; p = 0.019)/(OR = 0.483; 95% CI 0.245, 0.954; p = 0.036) were less susceptible for OA occurrence. Interestingly, we found OA patients also exhibited a general increase in mtDNA content. Our study indicates that the mtDNA haplogroup plays a role in modulating OA development.
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spelling pubmed-39588732014-03-20 Role of mtDNA Haplogroups in the Prevalence of Knee Osteoarthritis in a Southern Chinese Population Fang, Hezhi Liu, Xinwei Shen, Lijun Li, Fengjie Liu, Yihong Chi, Hongbo Miao, Huikai Lu, Jianxin Bai, Yidong Int J Mol Sci Article Mitochondrial DNA (mtDNA) has been implicated in various human degenerative diseases. However, the role of mtDNA in Osteoarthritis (OA) is less known. To investigate whether mtDNA haplogroups contribute to the prevalence of knee OA, we have carried out a comprehensive case-control study on 187 knee OA patients and 420 geographically matched controls in southern China. OA patients were classified on the Kellgren/Lawrence scale from two to four for the disease severity study and the data were analyzed by adjusting for age and sex. We found that patients with haplogroup G (OR = 3.834; 95% CI 1.139, 12.908; p = 0.03) and T16362C (OR = 1.715; 95% CI 1.174, 2.506; p = 0.005) exhibited an increased risk of OA occurrence. Furthermore, patients carrying haplogroup G had a higher severity progression of knee OA (OR = 10.870; 95% CI 1.307, 90.909; p = 0.007). On the other hand, people with haplogroup B/B4 (OR = 0.503; 95% CI 0.283, 0.893; p = 0.019)/(OR = 0.483; 95% CI 0.245, 0.954; p = 0.036) were less susceptible for OA occurrence. Interestingly, we found OA patients also exhibited a general increase in mtDNA content. Our study indicates that the mtDNA haplogroup plays a role in modulating OA development. Molecular Diversity Preservation International (MDPI) 2014-02-14 /pmc/articles/PMC3958873/ /pubmed/24534808 http://dx.doi.org/10.3390/ijms15022646 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Fang, Hezhi
Liu, Xinwei
Shen, Lijun
Li, Fengjie
Liu, Yihong
Chi, Hongbo
Miao, Huikai
Lu, Jianxin
Bai, Yidong
Role of mtDNA Haplogroups in the Prevalence of Knee Osteoarthritis in a Southern Chinese Population
title Role of mtDNA Haplogroups in the Prevalence of Knee Osteoarthritis in a Southern Chinese Population
title_full Role of mtDNA Haplogroups in the Prevalence of Knee Osteoarthritis in a Southern Chinese Population
title_fullStr Role of mtDNA Haplogroups in the Prevalence of Knee Osteoarthritis in a Southern Chinese Population
title_full_unstemmed Role of mtDNA Haplogroups in the Prevalence of Knee Osteoarthritis in a Southern Chinese Population
title_short Role of mtDNA Haplogroups in the Prevalence of Knee Osteoarthritis in a Southern Chinese Population
title_sort role of mtdna haplogroups in the prevalence of knee osteoarthritis in a southern chinese population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958873/
https://www.ncbi.nlm.nih.gov/pubmed/24534808
http://dx.doi.org/10.3390/ijms15022646
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