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Role of mtDNA Haplogroups in the Prevalence of Knee Osteoarthritis in a Southern Chinese Population
Mitochondrial DNA (mtDNA) has been implicated in various human degenerative diseases. However, the role of mtDNA in Osteoarthritis (OA) is less known. To investigate whether mtDNA haplogroups contribute to the prevalence of knee OA, we have carried out a comprehensive case-control study on 187 knee...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Molecular Diversity Preservation International (MDPI)
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958873/ https://www.ncbi.nlm.nih.gov/pubmed/24534808 http://dx.doi.org/10.3390/ijms15022646 |
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author | Fang, Hezhi Liu, Xinwei Shen, Lijun Li, Fengjie Liu, Yihong Chi, Hongbo Miao, Huikai Lu, Jianxin Bai, Yidong |
author_facet | Fang, Hezhi Liu, Xinwei Shen, Lijun Li, Fengjie Liu, Yihong Chi, Hongbo Miao, Huikai Lu, Jianxin Bai, Yidong |
author_sort | Fang, Hezhi |
collection | PubMed |
description | Mitochondrial DNA (mtDNA) has been implicated in various human degenerative diseases. However, the role of mtDNA in Osteoarthritis (OA) is less known. To investigate whether mtDNA haplogroups contribute to the prevalence of knee OA, we have carried out a comprehensive case-control study on 187 knee OA patients and 420 geographically matched controls in southern China. OA patients were classified on the Kellgren/Lawrence scale from two to four for the disease severity study and the data were analyzed by adjusting for age and sex. We found that patients with haplogroup G (OR = 3.834; 95% CI 1.139, 12.908; p = 0.03) and T16362C (OR = 1.715; 95% CI 1.174, 2.506; p = 0.005) exhibited an increased risk of OA occurrence. Furthermore, patients carrying haplogroup G had a higher severity progression of knee OA (OR = 10.870; 95% CI 1.307, 90.909; p = 0.007). On the other hand, people with haplogroup B/B4 (OR = 0.503; 95% CI 0.283, 0.893; p = 0.019)/(OR = 0.483; 95% CI 0.245, 0.954; p = 0.036) were less susceptible for OA occurrence. Interestingly, we found OA patients also exhibited a general increase in mtDNA content. Our study indicates that the mtDNA haplogroup plays a role in modulating OA development. |
format | Online Article Text |
id | pubmed-3958873 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-39588732014-03-20 Role of mtDNA Haplogroups in the Prevalence of Knee Osteoarthritis in a Southern Chinese Population Fang, Hezhi Liu, Xinwei Shen, Lijun Li, Fengjie Liu, Yihong Chi, Hongbo Miao, Huikai Lu, Jianxin Bai, Yidong Int J Mol Sci Article Mitochondrial DNA (mtDNA) has been implicated in various human degenerative diseases. However, the role of mtDNA in Osteoarthritis (OA) is less known. To investigate whether mtDNA haplogroups contribute to the prevalence of knee OA, we have carried out a comprehensive case-control study on 187 knee OA patients and 420 geographically matched controls in southern China. OA patients were classified on the Kellgren/Lawrence scale from two to four for the disease severity study and the data were analyzed by adjusting for age and sex. We found that patients with haplogroup G (OR = 3.834; 95% CI 1.139, 12.908; p = 0.03) and T16362C (OR = 1.715; 95% CI 1.174, 2.506; p = 0.005) exhibited an increased risk of OA occurrence. Furthermore, patients carrying haplogroup G had a higher severity progression of knee OA (OR = 10.870; 95% CI 1.307, 90.909; p = 0.007). On the other hand, people with haplogroup B/B4 (OR = 0.503; 95% CI 0.283, 0.893; p = 0.019)/(OR = 0.483; 95% CI 0.245, 0.954; p = 0.036) were less susceptible for OA occurrence. Interestingly, we found OA patients also exhibited a general increase in mtDNA content. Our study indicates that the mtDNA haplogroup plays a role in modulating OA development. Molecular Diversity Preservation International (MDPI) 2014-02-14 /pmc/articles/PMC3958873/ /pubmed/24534808 http://dx.doi.org/10.3390/ijms15022646 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Fang, Hezhi Liu, Xinwei Shen, Lijun Li, Fengjie Liu, Yihong Chi, Hongbo Miao, Huikai Lu, Jianxin Bai, Yidong Role of mtDNA Haplogroups in the Prevalence of Knee Osteoarthritis in a Southern Chinese Population |
title | Role of mtDNA Haplogroups in the Prevalence of Knee Osteoarthritis in a Southern Chinese Population |
title_full | Role of mtDNA Haplogroups in the Prevalence of Knee Osteoarthritis in a Southern Chinese Population |
title_fullStr | Role of mtDNA Haplogroups in the Prevalence of Knee Osteoarthritis in a Southern Chinese Population |
title_full_unstemmed | Role of mtDNA Haplogroups in the Prevalence of Knee Osteoarthritis in a Southern Chinese Population |
title_short | Role of mtDNA Haplogroups in the Prevalence of Knee Osteoarthritis in a Southern Chinese Population |
title_sort | role of mtdna haplogroups in the prevalence of knee osteoarthritis in a southern chinese population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958873/ https://www.ncbi.nlm.nih.gov/pubmed/24534808 http://dx.doi.org/10.3390/ijms15022646 |
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