Involvement of Hydrogen Peroxide in Safingol-Induced Endonuclease G-Mediated Apoptosis of Squamous Cell Carcinoma Cells

Safingol, a L-threo-dihydrosphingosine, induced the nuclear translocation of a mitochondrial apoptogenic mediator—endonuclease G (endo G)—and apoptosis of human oral squamous cell carcinoma (SCC) cells. Upstream mediators remain largely unknown. The levels of hydrogen peroxide (H(2)O(2)) in cultured...

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Detalles Bibliográficos
Autores principales: Hamada, Masakazu, Wakabayashi, Ken, Masui, Atsushi, Iwai, Soichi, Imai, Tomoaki, Yura, Yoshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958874/
https://www.ncbi.nlm.nih.gov/pubmed/24549171
http://dx.doi.org/10.3390/ijms15022660

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