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Shape and Site Dependent in Vivo Degradation of Mg-Zn Pins in Rabbit Femoral Condyle

A type of specially designed pin model of Mg-Zn alloy was implanted into the full thickness of lesions of New Zealand rabbits’ femoral condyles. The recovery progress, outer surface healing and in vivo degradation were characterized by various methods including radiographs, Micro-CT scan with surfac...

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Autores principales: Han, Pei, Tan, Moyan, Zhang, Shaoxiang, Ji, Weiping, Li, Jianan, Zhang, Xiaonong, Zhao, Changli, Zheng, Yufeng, Chai, Yimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958893/
https://www.ncbi.nlm.nih.gov/pubmed/24566138
http://dx.doi.org/10.3390/ijms15022959
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author Han, Pei
Tan, Moyan
Zhang, Shaoxiang
Ji, Weiping
Li, Jianan
Zhang, Xiaonong
Zhao, Changli
Zheng, Yufeng
Chai, Yimin
author_facet Han, Pei
Tan, Moyan
Zhang, Shaoxiang
Ji, Weiping
Li, Jianan
Zhang, Xiaonong
Zhao, Changli
Zheng, Yufeng
Chai, Yimin
author_sort Han, Pei
collection PubMed
description A type of specially designed pin model of Mg-Zn alloy was implanted into the full thickness of lesions of New Zealand rabbits’ femoral condyles. The recovery progress, outer surface healing and in vivo degradation were characterized by various methods including radiographs, Micro-CT scan with surface rendering, SEM (scanning electron microscope) with EDX (Energy Dispersive X-ray analysis) and so on. The in vivo results suggested that a few but not sufficient bridges for holding force were formed between the bone and the implant if there was a preexisting gap between them. The rapid degradation of the implantation in the condyle would result in the appearance of cavities. Morphological evaluation of the specially designed pins indicated that the cusp was the most vulnerable part during degradation. Furthermore, different implantation sites with distinct components and biological functions can lead to different degradation rates of Mg-Zn alloy. The rate of Mg-Zn alloy decreases in the following order: implantation into soft tissue, less trabecular bone, more trabecular bone, and cortical bone. Because of the complexities of in vivo degradation, it is necessary for the design of biomedical Mg-Zn devices to take into consideration the implantation sites used in clinics.
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spelling pubmed-39588932014-03-20 Shape and Site Dependent in Vivo Degradation of Mg-Zn Pins in Rabbit Femoral Condyle Han, Pei Tan, Moyan Zhang, Shaoxiang Ji, Weiping Li, Jianan Zhang, Xiaonong Zhao, Changli Zheng, Yufeng Chai, Yimin Int J Mol Sci Article A type of specially designed pin model of Mg-Zn alloy was implanted into the full thickness of lesions of New Zealand rabbits’ femoral condyles. The recovery progress, outer surface healing and in vivo degradation were characterized by various methods including radiographs, Micro-CT scan with surface rendering, SEM (scanning electron microscope) with EDX (Energy Dispersive X-ray analysis) and so on. The in vivo results suggested that a few but not sufficient bridges for holding force were formed between the bone and the implant if there was a preexisting gap between them. The rapid degradation of the implantation in the condyle would result in the appearance of cavities. Morphological evaluation of the specially designed pins indicated that the cusp was the most vulnerable part during degradation. Furthermore, different implantation sites with distinct components and biological functions can lead to different degradation rates of Mg-Zn alloy. The rate of Mg-Zn alloy decreases in the following order: implantation into soft tissue, less trabecular bone, more trabecular bone, and cortical bone. Because of the complexities of in vivo degradation, it is necessary for the design of biomedical Mg-Zn devices to take into consideration the implantation sites used in clinics. Molecular Diversity Preservation International (MDPI) 2014-02-20 /pmc/articles/PMC3958893/ /pubmed/24566138 http://dx.doi.org/10.3390/ijms15022959 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Han, Pei
Tan, Moyan
Zhang, Shaoxiang
Ji, Weiping
Li, Jianan
Zhang, Xiaonong
Zhao, Changli
Zheng, Yufeng
Chai, Yimin
Shape and Site Dependent in Vivo Degradation of Mg-Zn Pins in Rabbit Femoral Condyle
title Shape and Site Dependent in Vivo Degradation of Mg-Zn Pins in Rabbit Femoral Condyle
title_full Shape and Site Dependent in Vivo Degradation of Mg-Zn Pins in Rabbit Femoral Condyle
title_fullStr Shape and Site Dependent in Vivo Degradation of Mg-Zn Pins in Rabbit Femoral Condyle
title_full_unstemmed Shape and Site Dependent in Vivo Degradation of Mg-Zn Pins in Rabbit Femoral Condyle
title_short Shape and Site Dependent in Vivo Degradation of Mg-Zn Pins in Rabbit Femoral Condyle
title_sort shape and site dependent in vivo degradation of mg-zn pins in rabbit femoral condyle
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958893/
https://www.ncbi.nlm.nih.gov/pubmed/24566138
http://dx.doi.org/10.3390/ijms15022959
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