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Nanostructured Guidance for Peripheral Nerve Injuries: A Review with a Perspective in the Oral and Maxillofacial Area

Injury to peripheral nerves can occur as a result of various surgical procedures, including oral and maxillofacial surgery. In the case of nerve transaction, the gold standard treatment is the end-to-end reconnection of the two nerve stumps. When it cannot be performed, the actual strategies consist...

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Autores principales: Sivolella, Stefano, Brunello, Giulia, Ferrarese, Nadia, Puppa, Alessandro Della, D’Avella, Domenico, Bressan, Eriberto, Zavan, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958900/
https://www.ncbi.nlm.nih.gov/pubmed/24562333
http://dx.doi.org/10.3390/ijms15023088
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author Sivolella, Stefano
Brunello, Giulia
Ferrarese, Nadia
Puppa, Alessandro Della
D’Avella, Domenico
Bressan, Eriberto
Zavan, Barbara
author_facet Sivolella, Stefano
Brunello, Giulia
Ferrarese, Nadia
Puppa, Alessandro Della
D’Avella, Domenico
Bressan, Eriberto
Zavan, Barbara
author_sort Sivolella, Stefano
collection PubMed
description Injury to peripheral nerves can occur as a result of various surgical procedures, including oral and maxillofacial surgery. In the case of nerve transaction, the gold standard treatment is the end-to-end reconnection of the two nerve stumps. When it cannot be performed, the actual strategies consist of the positioning of a nerve graft between the two stumps. Guided nerve regeneration using nano-structured scaffolds is a promising strategy to promote axon regeneration. Biodegradable electrospun conduits composed of aligned nanofibers is a new class of devices used to improve neurite extension and axon outgrowth. Self assembled peptide nanofibrous scaffolds (SAPNSs) demonstrated promising results in animal models for central nervous system injuries, and, more recently, for peripheral nerve injury. Aims of this work are (1) to review electrospun and self-assembled nanofibrous scaffolds use in vitro and in vivo for peripheral nerve regeneration; and (2) its application in peripheral nerve injuries treatment. The review focused on nanofibrous scaffolds with a diameter of less than approximately 250 nm. The conjugation in a nano scale of a natural bioactive factor with a resorbable synthetic or natural material may represent the best compromise providing both biological and mechanical cues for guided nerve regeneration. Injured peripheral nerves, such as trigeminal and facial, may benefit from these treatments.
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spelling pubmed-39589002014-03-20 Nanostructured Guidance for Peripheral Nerve Injuries: A Review with a Perspective in the Oral and Maxillofacial Area Sivolella, Stefano Brunello, Giulia Ferrarese, Nadia Puppa, Alessandro Della D’Avella, Domenico Bressan, Eriberto Zavan, Barbara Int J Mol Sci Review Injury to peripheral nerves can occur as a result of various surgical procedures, including oral and maxillofacial surgery. In the case of nerve transaction, the gold standard treatment is the end-to-end reconnection of the two nerve stumps. When it cannot be performed, the actual strategies consist of the positioning of a nerve graft between the two stumps. Guided nerve regeneration using nano-structured scaffolds is a promising strategy to promote axon regeneration. Biodegradable electrospun conduits composed of aligned nanofibers is a new class of devices used to improve neurite extension and axon outgrowth. Self assembled peptide nanofibrous scaffolds (SAPNSs) demonstrated promising results in animal models for central nervous system injuries, and, more recently, for peripheral nerve injury. Aims of this work are (1) to review electrospun and self-assembled nanofibrous scaffolds use in vitro and in vivo for peripheral nerve regeneration; and (2) its application in peripheral nerve injuries treatment. The review focused on nanofibrous scaffolds with a diameter of less than approximately 250 nm. The conjugation in a nano scale of a natural bioactive factor with a resorbable synthetic or natural material may represent the best compromise providing both biological and mechanical cues for guided nerve regeneration. Injured peripheral nerves, such as trigeminal and facial, may benefit from these treatments. Molecular Diversity Preservation International (MDPI) 2014-02-20 /pmc/articles/PMC3958900/ /pubmed/24562333 http://dx.doi.org/10.3390/ijms15023088 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Sivolella, Stefano
Brunello, Giulia
Ferrarese, Nadia
Puppa, Alessandro Della
D’Avella, Domenico
Bressan, Eriberto
Zavan, Barbara
Nanostructured Guidance for Peripheral Nerve Injuries: A Review with a Perspective in the Oral and Maxillofacial Area
title Nanostructured Guidance for Peripheral Nerve Injuries: A Review with a Perspective in the Oral and Maxillofacial Area
title_full Nanostructured Guidance for Peripheral Nerve Injuries: A Review with a Perspective in the Oral and Maxillofacial Area
title_fullStr Nanostructured Guidance for Peripheral Nerve Injuries: A Review with a Perspective in the Oral and Maxillofacial Area
title_full_unstemmed Nanostructured Guidance for Peripheral Nerve Injuries: A Review with a Perspective in the Oral and Maxillofacial Area
title_short Nanostructured Guidance for Peripheral Nerve Injuries: A Review with a Perspective in the Oral and Maxillofacial Area
title_sort nanostructured guidance for peripheral nerve injuries: a review with a perspective in the oral and maxillofacial area
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958900/
https://www.ncbi.nlm.nih.gov/pubmed/24562333
http://dx.doi.org/10.3390/ijms15023088
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