Expression of human apolipoprotein E4 reduces insulin-receptor substrate 1 expression and Akt phosphorylation in the ageing liver

The diabetic drug rosiglitazone was reported to improve glucose tolerance in insulin-resistant ApoE3 but not ApoE4 knock-in mice. We therefore examined whether apolipoprotein E (ApoE) has genotype-specific effects on liver insulin function. At 12 weeks, no difference in liver insulin signaling was d...

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Detalles Bibliográficos
Autores principales: Ong, Qi-Rui, Chan, Elizabeth S., Lim, Mei-Li, Wong, Boon-Seng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958919/
https://www.ncbi.nlm.nih.gov/pubmed/24649407
http://dx.doi.org/10.1016/j.fob.2014.02.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958919/
https://www.ncbi.nlm.nih.gov/pubmed/24649407
http://dx.doi.org/10.1016/j.fob.2014.02.011

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