HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress

The HECT E3 ubiquitin ligase HACE1 is a tumour suppressor known to regulate Rac1 activity under stress conditions. HACE1 is increased in the serum of patients with heart failure. Here we show that HACE1 protects the heart under pressure stress by controlling protein degradation. Hace1 deficiency in...

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Detalles Bibliográficos
Autores principales: Zhang, Liyong, Chen, Xin, Sharma, Parveen, Moon, Mark, Sheftel, Alex D., Dawood, Fayez, Nghiem, Mai P., Wu, Jun, Li, Ren-Ke, Gramolini, Anthony O., Sorensen, Poul H., Penninger, Josef M., Brumell, John H., Liu, Peter P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959209/
https://www.ncbi.nlm.nih.gov/pubmed/24614889
http://dx.doi.org/10.1038/ncomms4430

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