Cargando…

Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway

Haem oxygenase (HO)-1/carbon monoxide (CO) protects cancer cells from oxidative stress, but the gas-responsive signalling mechanisms remain unknown. Here we show using metabolomics that CO-sensitive methylation of PFKFB3, an enzyme producing fructose 2,6-bisphosphate (F-2,6-BP), serves as a switch t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yamamoto, Takehiro, Takano, Naoharu, Ishiwata, Kyoko, Ohmura, Mitsuyo, Nagahata, Yoshiko, Matsuura, Tomomi, Kamata, Aki, Sakamoto, Kyoko, Nakanishi, Tsuyoshi, Kubo, Akiko, Hishiki, Takako, Suematsu, Makoto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959213/ https://www.ncbi.nlm.nih.gov/pubmed/24633012 http://dx.doi.org/10.1038/ncomms4480

Ejemplares similares

Carbon monoxide stimulates global protein methylation via its inhibitory action on cystathionine β-synthase
por: Yamamoto, Takehiro, et al.
Publicado: (2011)

Therapeutic hypothermia achieves neuroprotection via a decrease in acetylcholine with a concurrent increase in carnitine in the neonatal hypoxia-ischemia
por: Takenouchi, Toshiki, et al.
Publicado: (2015)

Neuroprotective Role of Astroglia in Parkinson Disease by Reducing Oxidative Stress Through Dopamine-Induced Activation of Pentose-Phosphate Pathway
por: Mashima, Kyoko, et al.
Publicado: (2018)

A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system
por: Iizumi, Takuya, et al.
Publicado: (2016)

Endotoxemia induces an early differential metabolic response in the heart and liver as determined by metabolomic analysis
por: Bateman, RM, et al.
Publicado: (2008)

Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration
por: Rodriguez-Rodriguez, P, et al.
Publicado: (2012)

Carbon monoxide: impact on remethylation/transsulfuration metabolism and its pathophysiologic implications
por: Hishiki, Takako, et al.
Publicado: (2012)

p53 coordinates DNA repair with nucleotide synthesis by suppressing PFKFB3 expression and promoting the pentose phosphate pathway
por: Franklin, Derek A., et al.
Publicado: (2016)

PFKFB4 is overexpressed in clear-cell renal cell carcinoma promoting pentose phosphate pathway that mediates Sunitinib resistance
por: Feng, Chenchen, et al.
Publicado: (2021)

Biochemical, Metabolomic, and Genetic Analyses of Dephospho Coenzyme A Kinase Involved in Coenzyme A Biosynthesis in the Human Enteric Parasite Entamoeba histolytica
por: Nurkanto, Arif, et al.
Publicado: (2018)

Correction to: PFKFB4 is overexpressed in clear-cell renal cell carcinoma promoting pentose phosphate pathway that mediates Sunitinib resistance
por: Feng, Chenchen, et al.
Publicado: (2021)

2-Nitroimidazoles induce mitochondrial stress and ferroptosis in glioma stem cells residing in a hypoxic niche
por: Koike, Naoyoshi, et al.
Publicado: (2020)

Characterization and validation of Entamoeba histolytica pantothenate kinase as a novel anti-amebic drug target
por: Nurkanto, Arif, et al.
Publicado: (2018)

Spatially restricted substrate-binding site of cortisol-synthesizing CYP11B1 limits multiple hydroxylations and hinders aldosterone synthesis
por: Mukai, Kuniaki, et al.
Publicado: (2021)

A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance
por: Milanese, Chiara, et al.
Publicado: (2020)

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival
por: Shiota, Megumi, et al.
Publicado: (2018)

Discovery of a novel glucose metabolism in cancer: The role of endoplasmic reticulum beyond glycolysis and pentose phosphate shunt
por: Marini, Cecilia, et al.
Publicado: (2016)

Pentose Phosphate Shunt Modulates Reactive Oxygen Species and Nitric Oxide Production Controlling Trypanosoma cruzi in Macrophages
por: Koo, Sue-jie, et al.
Publicado: (2018)

Glucose is preferentially utilized for biomass synthesis in pressure-overloaded hearts: evidence from fatty acid-binding protein-4 and -5 knockout mice
por: Umbarawan, Yogi, et al.
Publicado: (2018)

Semi-quantitative analyses of metabolic systems of human colon cancer metastatic xenografts in livers of superimmunodeficient NOG mice
por: Kubo, Akiko, et al.
Publicado: (2011)

Pentose Metabolism in Bacteria
por: Rose, Irwin A.
Publicado: (1963)

Roles of PFKFB3 in cancer
por: Shi, Linlin, et al.
Publicado: (2017)

Therapeutic targeting of PFKFB3 and PFKFB4 in multiple myeloma cells under hypoxic conditions
por: Okabe, Seiichi, et al.
Publicado: (2022)

Fatty Acid Synthesis Is Indispensable for Survival of Human Pluripotent Stem Cells
por: Tanosaki, Sho, et al.
Publicado: (2020)

The metabolic role of PFKFB4 in androgen-independent growth in vitro and PFKFB4 expression in human prostate cancer tissue
por: Li, Ximing, et al.
Publicado: (2020)

Role of PFKFB3 and PFKFB4 in Cancer: Genetic Basis, Impact on Disease Development/Progression, and Potential as Therapeutic Targets
por: Kotowski, Krzysztof, et al.
Publicado: (2021)

Role of PFKFB3-driven glycolysis in sepsis
por: Xiao, Min, et al.
Publicado: (2023)

Weight and Abdominal Pressure-Induced Shunt Trouble in Patients With Shunted Normal Pressure Hydrocephalus: A Comprehensive Study on Pressure Environment of Shunt System
por: Kamo, Masatsugu, et al.
Publicado: (2022)

Regulation of the pentose phosphate pathway in cancer
por: Jiang, Peng, et al.
Publicado: (2014)

Ketogenic diet in action: Metabolic profiling of pyruvate dehydrogenase deficiency
por: Ogawa, Eri, et al.
Publicado: (2023)

The influence of PFK-II overexpression on neuroblastoma patients’ survival may be dependent on the particular isoenzyme expressed, PFKFB3 or PFKFB4
por: Trojan, Sonia E., et al.
Publicado: (2019)

The Entner-Doudoroff and Nonoxidative Pentose Phosphate Pathways Bypass Glycolysis and the Oxidative Pentose Phosphate Pathway in Ralstonia solanacearum
por: Jyoti, Poonam, et al.
Publicado: (2020)

PFKFB3: A Potential Key to Ocular Angiogenesis
por: Zhou, Zi-Yi, et al.
Publicado: (2021)

Functional diversity of PFKFB3 splice variants in glioblastomas
por: Heydasch, Ulli, et al.
Publicado: (2021)

Inhibition of the Carcinogenic Properties of Urethane by Pentose Nucleotides
por: Cowen, P. N.
Publicado: (1949)

The Pentose Phosphate Pathway Regulates the Circadian Clock
por: Rey, Guillaume, et al.
Publicado: (2016)

The Genetic Requirements for Pentose Fermentation in Budding Yeast
por: Mittelman, Karin, et al.
Publicado: (2017)

The Role of the Pentose Phosphate Pathway in Diabetes and Cancer
por: Ge, Tongxin, et al.
Publicado: (2020)

Queueing theory model of pentose phosphate pathway
por: Kloska, Sylwester M., et al.
Publicado: (2022)

Pentose Phosphate Pathway Reactions in Photosynthesizing Cells
por: Sharkey, Thomas D.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_gks4poa2ebfr4bi6d2s5gmb2ua