Innate immunity: a new chapter for hepatitis C

The immune response to hepatitis C virus (HCV) and the mechanisms leading to successful resolution are complex. Much work has been done on understanding the adaptive immune response to HCV due to the imperative of trying to find a vaccine. However the importance of the innate immune system is being...

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Detalles Bibliográficos
Autores principales: Hydes, Theresa, Khakoo, Salim I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hellenic Society of Gastroenterology 2012
Materias:
Invited Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959377/
https://www.ncbi.nlm.nih.gov/pubmed/24714071
Descripción
Sumario:The immune response to hepatitis C virus (HCV) and the mechanisms leading to successful resolution are complex. Much work has been done on understanding the adaptive immune response to HCV due to the imperative of trying to find a vaccine. However the importance of the innate immune system is being increasingly recognized. This has culminated in the discovery of IL-28B as a key genetic element in recovery from HCV in diverse populations. This association is one of the strongest in anti-viral immunity and represents a paradigm shift in how we view the immune response to HCV infection.

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