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Cardiorespiratory Fitness in Breast Cancer Patients: A Call for Normative Values
BACKGROUND: There is emerging evidence that adjuvant treatments for breast cancer negatively impact cardiorespiratory fitness (CRF) or Vo(2max), a key predictor of cardiovascular risk. Although a number of studies have measured CRF in breast cancer patients, there is currently limited data regarding...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959685/ https://www.ncbi.nlm.nih.gov/pubmed/24419734 http://dx.doi.org/10.1161/JAHA.113.000432 |
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author | Peel, Amanda B. Thomas, Samantha M. Dittus, Kim Jones, Lee W. Lakoski, Susan G. |
author_facet | Peel, Amanda B. Thomas, Samantha M. Dittus, Kim Jones, Lee W. Lakoski, Susan G. |
author_sort | Peel, Amanda B. |
collection | PubMed |
description | BACKGROUND: There is emerging evidence that adjuvant treatments for breast cancer negatively impact cardiorespiratory fitness (CRF) or Vo(2max), a key predictor of cardiovascular risk. Although a number of studies have measured CRF in breast cancer patients, there is currently limited data regarding expected CRF values in this patient population. Given that CRF is a poor prognostic sign and recently highlighted as a key measure to standardize by the American Heart Association, we sought to review the available literature on CRF among breast cancer patients. METHODS AND RESULTS: We identified 27 clinical trials and observational studies measuring Vo(2max) in the pre– and post–adjuvant treatment setting for breast cancer. We compared Vo(2max) before to Vo(2max) after adjuvant therapy and compared Vo(2max) in female breast cancer patients with Vo(2max) in healthy controls. CONCLUSIONS: We found that CRF was substantially lower in women with a history of breast cancer compared with healthy women and this was most pronounced among breast cancer patients in the post‐adjuvant setting. We conclude that knowledge of normative CRF values is critical to tailor appropriately timed exercise interventions in breast cancer patients susceptible to low CRF and subsequent cardiovascular risk. |
format | Online Article Text |
id | pubmed-3959685 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-39596852014-03-20 Cardiorespiratory Fitness in Breast Cancer Patients: A Call for Normative Values Peel, Amanda B. Thomas, Samantha M. Dittus, Kim Jones, Lee W. Lakoski, Susan G. J Am Heart Assoc Original Research BACKGROUND: There is emerging evidence that adjuvant treatments for breast cancer negatively impact cardiorespiratory fitness (CRF) or Vo(2max), a key predictor of cardiovascular risk. Although a number of studies have measured CRF in breast cancer patients, there is currently limited data regarding expected CRF values in this patient population. Given that CRF is a poor prognostic sign and recently highlighted as a key measure to standardize by the American Heart Association, we sought to review the available literature on CRF among breast cancer patients. METHODS AND RESULTS: We identified 27 clinical trials and observational studies measuring Vo(2max) in the pre– and post–adjuvant treatment setting for breast cancer. We compared Vo(2max) before to Vo(2max) after adjuvant therapy and compared Vo(2max) in female breast cancer patients with Vo(2max) in healthy controls. CONCLUSIONS: We found that CRF was substantially lower in women with a history of breast cancer compared with healthy women and this was most pronounced among breast cancer patients in the post‐adjuvant setting. We conclude that knowledge of normative CRF values is critical to tailor appropriately timed exercise interventions in breast cancer patients susceptible to low CRF and subsequent cardiovascular risk. Blackwell Publishing Ltd 2014-02-28 /pmc/articles/PMC3959685/ /pubmed/24419734 http://dx.doi.org/10.1161/JAHA.113.000432 Text en © 2014 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Research Peel, Amanda B. Thomas, Samantha M. Dittus, Kim Jones, Lee W. Lakoski, Susan G. Cardiorespiratory Fitness in Breast Cancer Patients: A Call for Normative Values |
title | Cardiorespiratory Fitness in Breast Cancer Patients: A Call for Normative Values |
title_full | Cardiorespiratory Fitness in Breast Cancer Patients: A Call for Normative Values |
title_fullStr | Cardiorespiratory Fitness in Breast Cancer Patients: A Call for Normative Values |
title_full_unstemmed | Cardiorespiratory Fitness in Breast Cancer Patients: A Call for Normative Values |
title_short | Cardiorespiratory Fitness in Breast Cancer Patients: A Call for Normative Values |
title_sort | cardiorespiratory fitness in breast cancer patients: a call for normative values |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959685/ https://www.ncbi.nlm.nih.gov/pubmed/24419734 http://dx.doi.org/10.1161/JAHA.113.000432 |
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