Cargando…

Direct Renin Inhibition With Aliskiren Protects Against Myocardial Ischemia/Reperfusion Injury by Activating Nitric Oxide Synthase Signaling in Spontaneously Hypertensive Rats

BACKGROUND: We tested the hypothesis that direct renin inhibition with aliskiren protects against myocardial ischemia/reperfusion (I/R) injury in spontaneously hypertensive rats (SHR), and examined the mechanism by which this occurs. METHODS AND RESULTS: Male SHR were treated (orally, 4 weeks) with...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Wen, Han, Yi, Meng, Guoliang, Bai, Wenli, Xie, Liping, Lu, Hui, Shao, Yongfeng, Wei, Lei, Pan, Shiyang, Zhou, Suming, Chen, Qi, Ferro, Albert, Ji, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2014
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959716/ https://www.ncbi.nlm.nih.gov/pubmed/24473199 http://dx.doi.org/10.1161/JAHA.113.000606

Ejemplares similares

Renin inhibition with aliskiren in hypertension: focus on aliskiren/hydrochlorothiazide combination therapy
por: Sureshkumar, Kalathil K
Publicado: (2008)

Aliskiren: An orally active renin inhibitor
por: Wal, Pranay, et al.
Publicado: (2011)

Direct Renin Inhibition: Focus on Aliskiren
por: Pool, James L.
Publicado: (2007)

Soy Isoflavone Protects Myocardial Ischemia/Reperfusion Injury through Increasing Endothelial Nitric Oxide Synthase and Decreasing Oxidative Stress in Ovariectomized Rats
por: Tang, Yan, et al.
Publicado: (2016)

Direct Renin Inhibitor: Aliskiren in Chronic Kidney Disease
por: Morishita, Yoshiyuki, et al.
Publicado: (2012)

Renin Inhibition with Aliskiren: A Decade of Clinical Experience
por: Pantzaris, Nikolaos-Dimitrios, et al.
Publicado: (2017)

The Dual Role of Inducible Nitric Oxide Synthase in Myocardial Ischemia/Reperfusion Injury: Friend or Foe?
por: Yu, Xin, et al.
Publicado: (2018)

l-Tetrahydropalmatine, an Active Component of Corydalis yanhusuo W.T. Wang, Protects against Myocardial Ischaemia-Reperfusion Injury in Rats
por: Han, Yi, et al.
Publicado: (2012)

Effects of Aliskiren on Stroke in Rats Expressing Human Renin and Angiotensinogen Genes
por: Schmerbach, Kristin, et al.
Publicado: (2010)

Direct Renin Inhibition with Aliskiren Improves Ischemia-Induced Neovasculogenesis in Diabetic Animals via the SDF-1 Related Mechanism
por: Chang, Ting-Ting, et al.
Publicado: (2015)

The renin angiotensin system in the development of cardiovascular disease: role of aliskiren in risk reduction
por: Verdecchia, Paolo, et al.
Publicado: (2008)

Renin-angiotensin-aldosterone system in the elderly: rational use of aliskiren in managing hypertension
por: Andersen, Karl
Publicado: (2009)

Antidepressant-like Effects of Renin Inhibitor Aliskiren in an Inflammatory Mouse Model of Depression
por: Alzarea, Sami I., et al.
Publicado: (2022)

Effect of the Direct Renin Inhibitor Aliskiren on Urinary Albumin Excretion in Spontaneous Type 2 Diabetic KK-A (y) Mouse
por: Furukawa, Masako, et al.
Publicado: (2013)

GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in rats
por: Meng, Guoliang, et al.
Publicado: (2015)

Successful Treatment of Hypertension in Anuric Hemodialysis Patients with a Direct Renin Inhibitor, Aliskiren
por: Maeda, Yoshitaka, et al.
Publicado: (2011)

Aliskiren, Fosinopril, and Their Outcome on Renin-Angiotensin-Aldosterone System (RAAS) in Rats with Thyroid Dysfunction
por: Farhadi, Susan A. S., et al.
Publicado: (2019)

Renoprotection, renin inhibition, and blood pressure control: the impact of aliskiren on integrated blood pressure control
por: Rashid, Haroon-Ur
Publicado: (2010)

Effects of Endothelin-1 and nitric oxide levels on myocardial ischemia-reperfusion injury
por: Ai, Wenwei, et al.
Publicado: (2022)

Aliskiren – an orally active renin inhibitor. Review of pharmacology, pharmacodynamics, kinetics, and clinical potential in the treatment of hypertension
por: Allikmets, Kristina
Publicado: (2007)

Pharmacovigilance analysis of adverse event reports for aliskiren hemifumarate, a first-in-class direct renin inhibitor
por: Ali, Ayad K
Publicado: (2011)

Long-term effects of aliskiren on blood pressure and the renin-angiotensin-aldosterone system in hypertensive hemodialysis patients
por: Morishita, Yoshiyuki, et al.
Publicado: (2012)

Effect of add-on direct renin inhibitor aliskiren in patients with non-diabetes related chronic kidney disease
por: Li, Szu-yuan, et al.
Publicado: (2012)

Expression of neuronal nitric oxide synthase and renin in dysplastic kidneys of young dogs
por: YABUKI, Akira, et al.
Publicado: (2021)

Roles of Nitric Oxide in Brain Ischemia and Reperfusion
por: Wang, Yijie, et al.
Publicado: (2022)

Aliskiren has chondroprotective efficacy in a rat model of osteoarthritis through suppression of the local renin-angiotensin system
por: Yan, Kaizhong, et al.
Publicado: (2017)

Rosiglitazone Affects Nitric Oxide Synthases and Improves Renal Outcome in a Rat Model of Severe Ischemia/Reperfusion Injury
por: Betz, Boris, et al.
Publicado: (2012)

Differential effects of selective and non-selective nitric oxide synthase inhibitors on the blood perfusion of ischemia-reperfused myocardium in dogs
por: Luo, Yi, et al.
Publicado: (2013)

Protective Effects of Nanoparticle-Loaded Aliskiren on Cardiovascular System in Spontaneously Hypertensive Rats
por: Pechanova, Olga, et al.
Publicado: (2019)

Prostaglandin E(2) reduces swine myocardial ischemia reperfusion injury via increased endothelial nitric oxide synthase and vascular endothelial growth factor expression levels
por: Zhou, Ying, et al.
Publicado: (2017)

Treatment combining aliskiren with paricalcitol is effective against progressive renal tubulointerstitial fibrosis via dual blockade of intrarenal renin
por: Chung, Sungjin, et al.
Publicado: (2017)

Aliskiren, ALTITUDE, and the implications for ATMOSPHERE
por: McMurray, John J.V., et al.
Publicado: (2012)

Roles of the nitric oxide signaling pathway in cardiac ischemic preconditioning against myocardial ischemia-reperfusion injury
por: Weerateerangkul, Punate, et al.
Publicado: (2011)

The Effects of Ischemic Postconditioning on Myocardial Function and Nitric Oxide Metabolites Following Ischemia-Reperfusion in Hyperthyroid Rats
por: Zaman, Jalal, et al.
Publicado: (2014)

Zofenopril Protects Against Myocardial Ischemia–Reperfusion Injury by Increasing Nitric Oxide and Hydrogen Sulfide Bioavailability
por: Donnarumma, Erminia, et al.
Publicado: (2016)

Role of cardiac renin angiotensin system in ischemia reperfusion injury and preconditioning of heart
por: Agrawal, Vimal, et al.
Publicado: (2016)

Ischemic postconditioning protects the heart against ischemia–reperfusion injury via neuronal nitric oxide synthase in the sarcoplasmic reticulum and mitochondria
por: Hu, L, et al.
Publicado: (2016)

The Role of Vasodilator Receptors of Renin–angiotensin System on Nitric Oxide Formation and Kidney Circulation after Angiotensin II Infusion in Renal Ischemia/Reperfusion Rats
por: Maleki, Maryam, et al.
Publicado: (2018)

The effect of combination treatment with aliskiren and blockers of the renin-angiotensin system on hyperkalaemia and acute kidney injury: systematic review and meta-analysis
por: Harel, Ziv, et al.
Publicado: (2012)

Aliskiren suppresses the renin–angiotensin–aldosterone system and reduces blood pressure and albuminuria in elderly chronic kidney disease patients with hypertension
por: Morishita, Yoshiyuki, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_a3tmempp10n2t2ekdd2vmiver3