Role of non-acid reflux in patients with non-erosive reflux disease

Non-erosive reflux disease (NERD) is the most common presentation of gastroesophageal reflux disease. Although acid reflux is the most important cause of symptom generation in NERD patients, non-acid reflux is also associated with reflux symptoms. The temporal relation between symptoms and reflux ep...

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Detalles Bibliográficos
Autores principales: Karamanolis, Georgios P., Tutuian, Radu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hellenic Society of Gastroenterology 2013
Materias:
Invited Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959947/
https://www.ncbi.nlm.nih.gov/pubmed/24714866
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author Karamanolis, Georgios P.
Tutuian, Radu
author_facet Karamanolis, Georgios P.
Tutuian, Radu
author_sort Karamanolis, Georgios P.
collection PubMed
description Non-erosive reflux disease (NERD) is the most common presentation of gastroesophageal reflux disease. Although acid reflux is the most important cause of symptom generation in NERD patients, non-acid reflux is also associated with reflux symptoms. The temporal relation between symptoms and reflux episodes is of importance in evaluating the results of combined pH-impedance monitoring in NERD patients. Mucosal hypersensitivity and mechanical stimulation due to great volume of non-acid reflux are among the putative mechanisms of symptom generation.
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spelling pubmed-39599472014-04-07 Role of non-acid reflux in patients with non-erosive reflux disease Karamanolis, Georgios P. Tutuian, Radu Ann Gastroenterol Invited Review Non-erosive reflux disease (NERD) is the most common presentation of gastroesophageal reflux disease. Although acid reflux is the most important cause of symptom generation in NERD patients, non-acid reflux is also associated with reflux symptoms. The temporal relation between symptoms and reflux episodes is of importance in evaluating the results of combined pH-impedance monitoring in NERD patients. Mucosal hypersensitivity and mechanical stimulation due to great volume of non-acid reflux are among the putative mechanisms of symptom generation. Hellenic Society of Gastroenterology 2013 /pmc/articles/PMC3959947/ /pubmed/24714866 Text en Copyright: © Hellenic Society of Gastroenterology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Invited Review
Karamanolis, Georgios P.
Tutuian, Radu
Role of non-acid reflux in patients with non-erosive reflux disease
title Role of non-acid reflux in patients with non-erosive reflux disease
title_full Role of non-acid reflux in patients with non-erosive reflux disease
title_fullStr Role of non-acid reflux in patients with non-erosive reflux disease
title_full_unstemmed Role of non-acid reflux in patients with non-erosive reflux disease
title_short Role of non-acid reflux in patients with non-erosive reflux disease
title_sort role of non-acid reflux in patients with non-erosive reflux disease
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959947/
https://www.ncbi.nlm.nih.gov/pubmed/24714866
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