A novel system for cloning human TCRs: Cutting short the way to TCR-based anticancer therapy

T-cell receptor (TCR)-based gene immunotherapy has emerged as a promising approach for the treatment of multiple malignancies. We have recently reported an efficient system for the cloning and functional evaluation of TCR-coding cDNAs. This system, which we named hTEC10, allows for the determination...

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Detalles Bibliográficos
Autores principales: Kobayashi, Eiji, Kishi, Hiroyuki, Muraguchi, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960297/
https://www.ncbi.nlm.nih.gov/pubmed/24653962
http://dx.doi.org/10.4161/onci.27258
Descripción
Sumario:T-cell receptor (TCR)-based gene immunotherapy has emerged as a promising approach for the treatment of multiple malignancies. We have recently reported an efficient system for the cloning and functional evaluation of TCR-coding cDNAs. This system, which we named hTEC10, allows for the determination of TCR antigen specificity in less than 10 days, and may therefore constitute a fast and powerful platform for the development of new TCR-based anticancer therapies.

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