A novel system for cloning human TCRs: Cutting short the way to TCR-based anticancer therapy

T-cell receptor (TCR)-based gene immunotherapy has emerged as a promising approach for the treatment of multiple malignancies. We have recently reported an efficient system for the cloning and functional evaluation of TCR-coding cDNAs. This system, which we named hTEC10, allows for the determination...

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Detalles Bibliográficos
Autores principales: Kobayashi, Eiji, Kishi, Hiroyuki, Muraguchi, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960297/
https://www.ncbi.nlm.nih.gov/pubmed/24653962
http://dx.doi.org/10.4161/onci.27258
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author Kobayashi, Eiji
Kishi, Hiroyuki
Muraguchi, Atsushi
author_facet Kobayashi, Eiji
Kishi, Hiroyuki
Muraguchi, Atsushi
author_sort Kobayashi, Eiji
collection PubMed
description T-cell receptor (TCR)-based gene immunotherapy has emerged as a promising approach for the treatment of multiple malignancies. We have recently reported an efficient system for the cloning and functional evaluation of TCR-coding cDNAs. This system, which we named hTEC10, allows for the determination of TCR antigen specificity in less than 10 days, and may therefore constitute a fast and powerful platform for the development of new TCR-based anticancer therapies.
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spelling pubmed-39602972014-03-20 A novel system for cloning human TCRs: Cutting short the way to TCR-based anticancer therapy Kobayashi, Eiji Kishi, Hiroyuki Muraguchi, Atsushi Oncoimmunology Author's View T-cell receptor (TCR)-based gene immunotherapy has emerged as a promising approach for the treatment of multiple malignancies. We have recently reported an efficient system for the cloning and functional evaluation of TCR-coding cDNAs. This system, which we named hTEC10, allows for the determination of TCR antigen specificity in less than 10 days, and may therefore constitute a fast and powerful platform for the development of new TCR-based anticancer therapies. Landes Bioscience 2014-01-01 /pmc/articles/PMC3960297/ /pubmed/24653962 http://dx.doi.org/10.4161/onci.27258 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Kobayashi, Eiji
Kishi, Hiroyuki
Muraguchi, Atsushi
A novel system for cloning human TCRs: Cutting short the way to TCR-based anticancer therapy
title A novel system for cloning human TCRs: Cutting short the way to TCR-based anticancer therapy
title_full A novel system for cloning human TCRs: Cutting short the way to TCR-based anticancer therapy
title_fullStr A novel system for cloning human TCRs: Cutting short the way to TCR-based anticancer therapy
title_full_unstemmed A novel system for cloning human TCRs: Cutting short the way to TCR-based anticancer therapy
title_short A novel system for cloning human TCRs: Cutting short the way to TCR-based anticancer therapy
title_sort novel system for cloning human tcrs: cutting short the way to tcr-based anticancer therapy
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960297/
https://www.ncbi.nlm.nih.gov/pubmed/24653962
http://dx.doi.org/10.4161/onci.27258
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