Early predictive value of multifunctional skin-infiltrating lymphocytes in anticancer immunotherapy

Bioassays that predict clinical outcome are essential to optimize cellular anticancer immunotherapy. We have recently developed a robust and simple skin test to evaluate the capacity of tumor-specific T cells to migrate, recognize their targets and exert effector functions. This bioassay detects T c...

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Detalles Bibliográficos
Autores principales: Wimmers, Florian, Aarntzen, Erik HJG, Schreibelt, Gerty, Jacobs, Joannes FM, JA Punt, Cornelis, Figdor, Carl G, de Vries, I Jolanda M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960298/
https://www.ncbi.nlm.nih.gov/pubmed/24653961
http://dx.doi.org/10.4161/onci.27219
Descripción
Sumario:Bioassays that predict clinical outcome are essential to optimize cellular anticancer immunotherapy. We have recently developed a robust and simple skin test to evaluate the capacity of tumor-specific T cells to migrate, recognize their targets and exert effector functions. This bioassay detects T cells with an elevated antineoplastic potential and hence rapidly identifies patients responding to immunotherapy.

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