Anticancer effects of gemcitabine are enhanced by co-administered iRGD peptide in murine pancreatic cancer models that overexpressed neuropilin-1

BACKGROUND: Impaired drug transport is an important factor that reduces the efficacy of anticancer agents against pancreatic cancer. Here, we report a novel combination chemotherapy using gemcitabine (GEM) and internalised-RGD (iRGD) peptide, which enhances tumour-specific drug penetration by bindin...

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Detalles Bibliográficos
Autores principales: Akashi, Y, Oda, T, Ohara, Y, Miyamoto, R, Kurokawa, T, Hashimoto, S, Enomoto, T, Yamada, K, Satake, M, Ohkohchi, N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960621/
https://www.ncbi.nlm.nih.gov/pubmed/24556620
http://dx.doi.org/10.1038/bjc.2014.49

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960621/
https://www.ncbi.nlm.nih.gov/pubmed/24556620
http://dx.doi.org/10.1038/bjc.2014.49

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