Delayed triggering of oestrogen induced apoptosis that contrasts with rapid paclitaxel-induced breast cancer cell death

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BACKGROUND: Oestrogen (E(2)) induces apoptosis in long-term E(2)-deprived MCF7 cells (MCF7:5C). Taxanes have been used extensively in the treatment of early and advanced breast cancer. We have interrogated the sequence of events that involve the apoptotic signalling pathway induced by E(2) in compar...

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Detalles Bibliográficos
Autores principales: Obiorah, I, Sengupta, S, Fan, P, Jordan, V C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960622/
https://www.ncbi.nlm.nih.gov/pubmed/24548860
http://dx.doi.org/10.1038/bjc.2014.50

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