Is the mazEF toxin-antitoxin system responsible for vancomycin resistance in clinical isolates of Enterococcus faecalis?

The current study was conducted to investigate the relationship between vancomycin-resistant Enterococcus faecalis (VRE) and the presence of mazEF toxin-antitoxin (TA) system, which may be useful as target for novel antimicrobial therapy concepts. The susceptibility of E. faecalis was determined by...

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Autores principales: Sadeghifard, Nourkhoda, Soheili, Sara, Sekawi, Zamberi, Ghafourian, Sobhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: German Medical Science GMS Publishing House 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960931/
https://www.ncbi.nlm.nih.gov/pubmed/24653969
http://dx.doi.org/10.3205/dgkh000225
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author Sadeghifard, Nourkhoda
Soheili, Sara
Sekawi, Zamberi
Ghafourian, Sobhan
author_facet Sadeghifard, Nourkhoda
Soheili, Sara
Sekawi, Zamberi
Ghafourian, Sobhan
author_sort Sadeghifard, Nourkhoda
collection PubMed
description The current study was conducted to investigate the relationship between vancomycin-resistant Enterococcus faecalis (VRE) and the presence of mazEF toxin-antitoxin (TA) system, which may be useful as target for novel antimicrobial therapy concepts. The susceptibility of E. faecalis was determined by MIC, and the presence of the mazEF TA system was evaluated by PCR. Among 200 E. faecalis isolates 39.5% showed resistance to vancomycin (VRE), while 60.5% were susceptible strains (VSE). The mazEF TA system was positive in all VRE isolates (100%), but less prevalent (38/121, 31.4%) among the 121 VSE strains. In conclusion, our study demonstrated a positive relationship between the presence of vancomycin resistance and mazEF TA system. This observation may introduce therapeutic options against a novel antimicrobial target in enterococci.
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spelling pubmed-39609312014-03-20 Is the mazEF toxin-antitoxin system responsible for vancomycin resistance in clinical isolates of Enterococcus faecalis? Sadeghifard, Nourkhoda Soheili, Sara Sekawi, Zamberi Ghafourian, Sobhan GMS Hyg Infect Control Article The current study was conducted to investigate the relationship between vancomycin-resistant Enterococcus faecalis (VRE) and the presence of mazEF toxin-antitoxin (TA) system, which may be useful as target for novel antimicrobial therapy concepts. The susceptibility of E. faecalis was determined by MIC, and the presence of the mazEF TA system was evaluated by PCR. Among 200 E. faecalis isolates 39.5% showed resistance to vancomycin (VRE), while 60.5% were susceptible strains (VSE). The mazEF TA system was positive in all VRE isolates (100%), but less prevalent (38/121, 31.4%) among the 121 VSE strains. In conclusion, our study demonstrated a positive relationship between the presence of vancomycin resistance and mazEF TA system. This observation may introduce therapeutic options against a novel antimicrobial target in enterococci. German Medical Science GMS Publishing House 2014-03-07 /pmc/articles/PMC3960931/ /pubmed/24653969 http://dx.doi.org/10.3205/dgkh000225 Text en Copyright © 2014 Sadeghifard et al. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/). You are free to copy, distribute and transmit the work, provided the original author and source are credited.
spellingShingle Article
Sadeghifard, Nourkhoda
Soheili, Sara
Sekawi, Zamberi
Ghafourian, Sobhan
Is the mazEF toxin-antitoxin system responsible for vancomycin resistance in clinical isolates of Enterococcus faecalis?
title Is the mazEF toxin-antitoxin system responsible for vancomycin resistance in clinical isolates of Enterococcus faecalis?
title_full Is the mazEF toxin-antitoxin system responsible for vancomycin resistance in clinical isolates of Enterococcus faecalis?
title_fullStr Is the mazEF toxin-antitoxin system responsible for vancomycin resistance in clinical isolates of Enterococcus faecalis?
title_full_unstemmed Is the mazEF toxin-antitoxin system responsible for vancomycin resistance in clinical isolates of Enterococcus faecalis?
title_short Is the mazEF toxin-antitoxin system responsible for vancomycin resistance in clinical isolates of Enterococcus faecalis?
title_sort is the mazef toxin-antitoxin system responsible for vancomycin resistance in clinical isolates of enterococcus faecalis?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960931/
https://www.ncbi.nlm.nih.gov/pubmed/24653969
http://dx.doi.org/10.3205/dgkh000225
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