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RGS4 regulates partial agonism of the M2 muscarinic receptor-activated K(+) currents

Partial agonists are used clinically to avoid overstimulation of receptor-mediated signalling, as they produce a submaximal response even at 100% receptor occupancy. The submaximal efficacy of partial agonists is due to conformational change of the agonist–receptor complex, which reduces effector ac...

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Detalles Bibliográficos
Autores principales:	Chen, I-Shan, Furutani, Kazuharu, Inanobe, Atsushi, Kurachi, Yoshihisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell publishing Ltd 2014
Materias:	Cardiovascular
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961084/ https://www.ncbi.nlm.nih.gov/pubmed/24421355 http://dx.doi.org/10.1113/jphysiol.2013.269803

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