Genome-Wide Meta-Analysis of Homocysteine and Methionine Metabolism Identifies Five One Carbon Metabolism Loci and a Novel Association of ALDH1L1 with Ischemic Stroke

Circulating homocysteine levels (tHcy), a product of the folate one carbon metabolism pathway (FOCM) through the demethylation of methionine, are heritable and are associated with an increased risk of common diseases such as stroke, cardiovascular disease (CVD), cancer and dementia. The FOCM is the...

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Detalles Bibliográficos
Autores principales: Williams, Stephen R., Yang, Qiong, Chen, Fang, Liu, Xuan, Keene, Keith L., Jacques, Paul, Chen, Wei-Min, Weinstein, Galit, Hsu, Fang-Chi, Beiser, Alexa, Wang, Liewei, Bookman, Ebony, Doheny, Kimberly F., Wolf, Philip A., Zilka, Michelle, Selhub, Jacob, Nelson, Sarah, Gogarten, Stephanie M., Worrall, Bradford B., Seshadri, Sudha, Sale, Michèle M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961178/
https://www.ncbi.nlm.nih.gov/pubmed/24651765
http://dx.doi.org/10.1371/journal.pgen.1004214

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