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High Genetic Diversity and Adaptive Potential of Two Simian Hemorrhagic Fever Viruses in a Wild Primate Population

Key biological properties such as high genetic diversity and high evolutionary rate enhance the potential of certain RNA viruses to adapt and emerge. Identifying viruses with these properties in their natural hosts could dramatically improve disease forecasting and surveillance. Recently, we discove...

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Autores principales: Bailey, Adam L., Lauck, Michael, Weiler, Andrea, Sibley, Samuel D., Dinis, Jorge M., Bergman, Zachary, Nelson, Chase W., Correll, Michael, Gleicher, Michael, Hyeroba, David, Tumukunde, Alex, Weny, Geoffrey, Chapman, Colin, Kuhn, Jens H., Hughes, Austin L., Friedrich, Thomas C., Goldberg, Tony L., O'Connor, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961216/
https://www.ncbi.nlm.nih.gov/pubmed/24651479
http://dx.doi.org/10.1371/journal.pone.0090714
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author Bailey, Adam L.
Lauck, Michael
Weiler, Andrea
Sibley, Samuel D.
Dinis, Jorge M.
Bergman, Zachary
Nelson, Chase W.
Correll, Michael
Gleicher, Michael
Hyeroba, David
Tumukunde, Alex
Weny, Geoffrey
Chapman, Colin
Kuhn, Jens H.
Hughes, Austin L.
Friedrich, Thomas C.
Goldberg, Tony L.
O'Connor, David H.
author_facet Bailey, Adam L.
Lauck, Michael
Weiler, Andrea
Sibley, Samuel D.
Dinis, Jorge M.
Bergman, Zachary
Nelson, Chase W.
Correll, Michael
Gleicher, Michael
Hyeroba, David
Tumukunde, Alex
Weny, Geoffrey
Chapman, Colin
Kuhn, Jens H.
Hughes, Austin L.
Friedrich, Thomas C.
Goldberg, Tony L.
O'Connor, David H.
author_sort Bailey, Adam L.
collection PubMed
description Key biological properties such as high genetic diversity and high evolutionary rate enhance the potential of certain RNA viruses to adapt and emerge. Identifying viruses with these properties in their natural hosts could dramatically improve disease forecasting and surveillance. Recently, we discovered two novel members of the viral family Arteriviridae: simian hemorrhagic fever virus (SHFV)-krc1 and SHFV-krc2, infecting a single wild red colobus (Procolobus rufomitratus tephrosceles) in Kibale National Park, Uganda. Nearly nothing is known about the biological properties of SHFVs in nature, although the SHFV type strain, SHFV-LVR, has caused devastating outbreaks of viral hemorrhagic fever in captive macaques. Here we detected SHFV-krc1 and SHFV-krc2 in 40% and 47% of 60 wild red colobus tested, respectively. We found viral loads in excess of 10(6)–10(7) RNA copies per milliliter of blood plasma for each of these viruses. SHFV-krc1 and SHFV-krc2 also showed high genetic diversity at both the inter- and intra-host levels. Analyses of synonymous and non-synonymous nucleotide diversity across viral genomes revealed patterns suggestive of positive selection in SHFV open reading frames (ORF) 5 (SHFV-krc2 only) and 7 (SHFV-krc1 and SHFV-krc2). Thus, these viruses share several important properties with some of the most rapidly evolving, emergent RNA viruses.
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spelling pubmed-39612162014-03-24 High Genetic Diversity and Adaptive Potential of Two Simian Hemorrhagic Fever Viruses in a Wild Primate Population Bailey, Adam L. Lauck, Michael Weiler, Andrea Sibley, Samuel D. Dinis, Jorge M. Bergman, Zachary Nelson, Chase W. Correll, Michael Gleicher, Michael Hyeroba, David Tumukunde, Alex Weny, Geoffrey Chapman, Colin Kuhn, Jens H. Hughes, Austin L. Friedrich, Thomas C. Goldberg, Tony L. O'Connor, David H. PLoS One Research Article Key biological properties such as high genetic diversity and high evolutionary rate enhance the potential of certain RNA viruses to adapt and emerge. Identifying viruses with these properties in their natural hosts could dramatically improve disease forecasting and surveillance. Recently, we discovered two novel members of the viral family Arteriviridae: simian hemorrhagic fever virus (SHFV)-krc1 and SHFV-krc2, infecting a single wild red colobus (Procolobus rufomitratus tephrosceles) in Kibale National Park, Uganda. Nearly nothing is known about the biological properties of SHFVs in nature, although the SHFV type strain, SHFV-LVR, has caused devastating outbreaks of viral hemorrhagic fever in captive macaques. Here we detected SHFV-krc1 and SHFV-krc2 in 40% and 47% of 60 wild red colobus tested, respectively. We found viral loads in excess of 10(6)–10(7) RNA copies per milliliter of blood plasma for each of these viruses. SHFV-krc1 and SHFV-krc2 also showed high genetic diversity at both the inter- and intra-host levels. Analyses of synonymous and non-synonymous nucleotide diversity across viral genomes revealed patterns suggestive of positive selection in SHFV open reading frames (ORF) 5 (SHFV-krc2 only) and 7 (SHFV-krc1 and SHFV-krc2). Thus, these viruses share several important properties with some of the most rapidly evolving, emergent RNA viruses. Public Library of Science 2014-03-20 /pmc/articles/PMC3961216/ /pubmed/24651479 http://dx.doi.org/10.1371/journal.pone.0090714 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle Research Article
Bailey, Adam L.
Lauck, Michael
Weiler, Andrea
Sibley, Samuel D.
Dinis, Jorge M.
Bergman, Zachary
Nelson, Chase W.
Correll, Michael
Gleicher, Michael
Hyeroba, David
Tumukunde, Alex
Weny, Geoffrey
Chapman, Colin
Kuhn, Jens H.
Hughes, Austin L.
Friedrich, Thomas C.
Goldberg, Tony L.
O'Connor, David H.
High Genetic Diversity and Adaptive Potential of Two Simian Hemorrhagic Fever Viruses in a Wild Primate Population
title High Genetic Diversity and Adaptive Potential of Two Simian Hemorrhagic Fever Viruses in a Wild Primate Population
title_full High Genetic Diversity and Adaptive Potential of Two Simian Hemorrhagic Fever Viruses in a Wild Primate Population
title_fullStr High Genetic Diversity and Adaptive Potential of Two Simian Hemorrhagic Fever Viruses in a Wild Primate Population
title_full_unstemmed High Genetic Diversity and Adaptive Potential of Two Simian Hemorrhagic Fever Viruses in a Wild Primate Population
title_short High Genetic Diversity and Adaptive Potential of Two Simian Hemorrhagic Fever Viruses in a Wild Primate Population
title_sort high genetic diversity and adaptive potential of two simian hemorrhagic fever viruses in a wild primate population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961216/
https://www.ncbi.nlm.nih.gov/pubmed/24651479
http://dx.doi.org/10.1371/journal.pone.0090714
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