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BxPC3 pancreatic cancer cells express a truncated Smad4 protein upon PI3K and mTOR inhibition
Smad4 is a critical regulator of transforming growth factor (TGF)-β signaling and is defective in numerous human cancers. In total, 30% of pancreatic cancers harbor a homozygous deletion of Smad4. The human pancreatic cancer cell line, BxPC3, has been reported to be Smad4-null due to a homozygous de...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
D.A. Spandidos
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961292/ https://www.ncbi.nlm.nih.gov/pubmed/24944686 http://dx.doi.org/10.3892/ol.2014.1833 |