DHX36 Enhances RIG-I Signaling by Facilitating PKR-Mediated Antiviral Stress Granule Formation

RIG-I is a DExD/H-box RNA helicase and functions as a critical cytoplasmic sensor for RNA viruses to initiate antiviral interferon (IFN) responses. Here we demonstrate that another DExD/H-box RNA helicase DHX36 is a key molecule for RIG-I signaling by regulating double-stranded RNA (dsRNA)-dependent...

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Detalles Bibliográficos
Autores principales: Yoo, Ji-Seung, Takahasi, Kiyohiro, Ng, Chen Seng, Ouda, Ryota, Onomoto, Koji, Yoneyama, Mitsutoshi, Lai, Janice Ching, Lattmann, Simon, Nagamine, Yoshikuni, Matsui, Tadashi, Iwabuchi, Kuniyoshi, Kato, Hiroki, Fujita, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961341/
https://www.ncbi.nlm.nih.gov/pubmed/24651521
http://dx.doi.org/10.1371/journal.ppat.1004012

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