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Progranulin-Derived Atsttrin Directly Binds to TNFRSF25 (DR3) and Inhibits TNF-Like Ligand 1A (TL1A) Activity

Atsttrin, a progranulin (PGRN)-derived molecule composed of three TNFR-binding domains of PGRN, binds to TNF receptors (TNFR) and is therapeutic against inflammatory arthritis. Here we screened the associations of Atsttrin and other members in TNFR subfamily, which led to the discovery of TNFRSF25 (...

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Detalles Bibliográficos
Autores principales:	Liu, Cui, Li, Xing-Xia, Gao, Wei, Liu, Wen, Liu, De-Shan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961393/ https://www.ncbi.nlm.nih.gov/pubmed/24651300 http://dx.doi.org/10.1371/journal.pone.0092743

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