Cargando…

3-Deazaneplanocin A (DZNep), an Inhibitor of S-Adenosylmethionine-dependent Methyltransferase, Promotes Erythroid Differentiation

EZH2, a core component of polycomb repressive complex 2 (PRC2), plays a role in transcriptional repression through histone H3 Lys-27 trimethylation and is involved in various biological processes, including hematopoiesis. It is well known that 3-deazaneplanocin A (DZNep), an inhibitor of S-adenosylm...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fujiwara, Tohru, Saitoh, Haruka, Inoue, Ai, Kobayashi, Masahiro, Okitsu, Yoko, Katsuoka, Yuna, Fukuhara, Noriko, Onishi, Yasushi, Ishizawa, Kenichi, Ichinohasama, Ryo, Harigae, Hideo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2014
Materias:	Gene Regulation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961643/ https://www.ncbi.nlm.nih.gov/pubmed/24492606 http://dx.doi.org/10.1074/jbc.M114.548651

Ejemplares similares

Expression profiling of ETO2-regulated miRNAs in erythroid cells: Possible influence on miRNA abundance()
por: Fujiwara, Tohru, et al.
Publicado: (2013)

A Low-Molecular-Weight Compound K7174 Represses Hepcidin: Possible Therapeutic Strategy against Anemia of Chronic Disease
por: Fujiwara, Tohru, et al.
Publicado: (2013)

3-Deazaneplanocin A (DZNep), an Inhibitor of the Histone Methyltransferase EZH2, Induces Apoptosis and Reduces Cell Migration in Chondrosarcoma Cells
por: Girard, Nicolas, et al.
Publicado: (2014)

Co-Treatment with the Epigenetic Drug, 3-Deazaneplanocin A (DZNep) and Cisplatin after DZNep Priming Enhances the Response to Platinum-Based Therapy in Chondrosarcomas
por: Lhuissier, Eva, et al.
Publicado: (2021)

Evaluation of the impact of S-adenosylmethionine-dependent methyltransferase inhibitor, 3-deazaneplanocin A, on tissue injury and cognitive function in mice
por: Lhuissier, Eva, et al.
Publicado: (2018)

High-Throughput siRNA Screening to Reveal GATA-2 Upstream Transcriptional Mechanisms in Hematopoietic Cells
por: Saito, Yo, et al.
Publicado: (2015)

Clinicopathological analysis of primary adrenal diffuse large B-cell lymphoma: effectiveness of rituximab-containing chemotherapy including central nervous system prophylaxis
por: Ichikawa, Satoshi, et al.
Publicado: (2013)

Biology of Heme in Mammalian Erythroid Cells and Related Disorders
por: Fujiwara, Tohru, et al.
Publicado: (2015)

The X Protein of Hepatitis B Virus Inhibits Apoptosis in Hepatoma Cells through Enhancing the Methionine Adenosyltransferase 2A Gene Expression and Reducing S-Adenosylmethionine Production
por: Liu, Quanyan, et al.
Publicado: (2011)

Functional Characterization of D9, a Novel Deazaneplanocin A (DZNep) Analog, in Targeting Acute Myeloid Leukemia (AML)
por: Jiang, Xia, et al.
Publicado: (2015)

New Insights on the Mechanism of Quinoline-based DNA Methyltransferase Inhibitors
por: Gros, Christina, et al.
Publicado: (2015)

The Methyltransferase WBSCR22/Merm1 Enhances Glucocorticoid Receptor Function and Is Regulated in Lung Inflammation and Cancer
por: Jangani, Maryam, et al.
Publicado: (2014)

Gene Expression Profiling Identifies HOXB4 as a Direct Downstream Target of GATA-2 in Human CD34+ Hematopoietic Cells
por: Fujiwara, Tohru, et al.
Publicado: (2012)

Methylation of Histone H3 on Lysine 4 by the Lysine Methyltransferase SET1 Protein Is Needed for Normal Clock Gene Expression
por: Raduwan, Hamidah, et al.
Publicado: (2013)

Successful Treatment of Aggressive Mature B-cell Lymphoma Mimicking Immune Thrombocytopenic Purpura
por: Ono, Koya, et al.
Publicado: (2018)

Unique Role of the WD-40 Repeat Protein 5 (WDR5) Subunit within the Mixed Lineage Leukemia 3 (MLL3) Histone Methyltransferase Complex
por: Shinsky, Stephen A., et al.
Publicado: (2015)

S-adenosylmethionine-dependent methyltransferase inhibitor DZNep blocks transcription and translation of SARS-CoV-2 genome with a low tendency to select for drug-resistant viral variants
por: Kumar, Ram, et al.
Publicado: (2022)

Vincristine therapy for severe and refractory immune thrombocytopenia following COVID-19 vaccination
por: Saito, Kei, et al.
Publicado: (2021)

Dynamics of absorption, metabolism, and excretion of 5-aminolevulinic acid in human intestinal Caco-2 cells
por: Saito, Kei, et al.
Publicado: (2017)

Primary adrenal extranodal NK/T-cell lymphoma: A case report and literature review
por: Ichikawa, Satoshi, et al.
Publicado: (2020)

Diffuse Large B-cell Lymphoma Presenting as Peritoneal Lymphomatosis: A Case Report and Literature Review
por: Ichikawa, Satoshi, et al.
Publicado: (2021)

Intron 1 GATA site enhances ALAS2 expression indispensably during erythroid differentiation
por: Zhang, Yingchi, et al.
Publicado: (2017)

Setd1a and NURF mediate chromatin dynamics and gene regulation during erythroid lineage commitment and differentiation
por: Li, Ying, et al.
Publicado: (2016)

Identification of preferential target sites for human DNA methyltransferases
por: Choi, Si Ho, et al.
Publicado: (2011)

A highly conserved SOX6 double binding site mediates SOX6 gene downregulation in erythroid cells
por: Cantu', Claudio, et al.
Publicado: (2011)

Long-term remission of primary refractory ALK-positive anaplastic large cell lymphoma after allogeneic hematopoietic stem cell transplantation
por: Miyazaki, Masahiro, et al.
Publicado: (2022)

DNA methyltransferase 3b preferentially associates with condensed chromatin
por: Kashiwagi, Katsunobu, et al.
Publicado: (2011)

The distinctive roles of erythroid specific activator GATA-1 and NF-E2 in transcription of the human fetal γ-globin genes
por: Woon Kim, Yea, et al.
Publicado: (2011)

Anaplastic multiple myeloma with MYC rearrangement
por: Ichikawa, Satoshi, et al.
Publicado: (2021)

Protein arginine methyltransferase 6 regulates multiple aspects of gene expression
por: Harrison, Matthew J., et al.
Publicado: (2010)

Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase
por: Dukatz, Michael, et al.
Publicado: (2020)

Successful Cord Blood Stem Cell Transplantation for Primary Cutaneous CD8-positive Aggressive Epidermotropic Cytotoxic T-cell Lymphoma Complicated with Cerebral Infiltration
por: Ichikawa, Satoshi, et al.
Publicado: (2018)

Histone methyltransferase SETD2 coordinates FACT recruitment with nucleosome dynamics during transcription
por: Carvalho, Sílvia, et al.
Publicado: (2013)

Cell-cycle regulation of non-enzymatic functions of the Drosophila methyltransferase PR-Set7
por: Zouaz, Amel, et al.
Publicado: (2018)

Ezh2 promotes clock function and hematopoiesis independent of histone methyltransferase activity in zebrafish
por: Zhong, Yingbin, et al.
Publicado: (2018)

Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism
por: van Welsem, Tibor, et al.
Publicado: (2018)

Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation
por: Galloway, Alison, et al.
Publicado: (2021)

On the accuracy of the epigenetic copy machine: comprehensive specificity analysis of the DNMT1 DNA methyltransferase
por: Adam, Sabrina, et al.
Publicado: (2023)

Pharmacogenetics of thiopurine therapy: from thiopurine S-methyltransferase to S-adenosylmethionine
por: Mlinarič-Raščan, Irena, et al.
Publicado: (2009)

Diversity and Regulation of S-Adenosylmethionine Dependent Methyltransferases in the Anhydrobiotic Midge
por: Deviatiiarov, Ruslan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_6jdj7lnusapp6eee0g696v7hjb