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Nonsurgical Strategies in Patients With NET Liver Metastases: A Protocol of Four Systematic Reviews

BACKGROUND: Patients diagnosed with neuroendocrine tumors (NETs) with hepatic metastases generally have a worse prognosis as compared with patients with nonmetastasized NETs. Due to tumor location and distant metastases, a surgical approach is often not possible and nonsurgical therapeutic strategie...

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Autores principales: Limani, Perparim, Tschuor, Christoph, Gort, Laura, Balmer, Bettina, Gu, Alexander, Ceresa, Christos, Raptis, Dimitri Aristotle, Lesurtel, Mickael, Puhan, Milo, Breitenstein, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JMIR Publications Inc. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961806/
https://www.ncbi.nlm.nih.gov/pubmed/24610518
http://dx.doi.org/10.2196/resprot.2893
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author Limani, Perparim
Tschuor, Christoph
Gort, Laura
Balmer, Bettina
Gu, Alexander
Ceresa, Christos
Raptis, Dimitri Aristotle
Lesurtel, Mickael
Puhan, Milo
Breitenstein, Stefan
author_facet Limani, Perparim
Tschuor, Christoph
Gort, Laura
Balmer, Bettina
Gu, Alexander
Ceresa, Christos
Raptis, Dimitri Aristotle
Lesurtel, Mickael
Puhan, Milo
Breitenstein, Stefan
author_sort Limani, Perparim
collection PubMed
description BACKGROUND: Patients diagnosed with neuroendocrine tumors (NETs) with hepatic metastases generally have a worse prognosis as compared with patients with nonmetastasized NETs. Due to tumor location and distant metastases, a surgical approach is often not possible and nonsurgical therapeutic strategies may apply. OBJECTIVE: The aim of these systematic reviews is to evaluate the role of nonsurgical therapy options for patients with nonresectable liver metastases of NETs. METHODS: An objective group of librarians will provide an electronic search strategy to examine the MEDLINE, EMBASE, and The Cochrane Library (Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials [CENTRAL]) databases. There will be no restriction concerning language and publication date. The qualitative and quantitative synthesis of the systematic review will be conducted with randomized controlled trials (RCT), prospective, and retrospective comparative cohort, and case-control studies. Case series will be collected in a separate database and only used for descriptive purposes. RESULTS: This study is ongoing and presents a protocol of four systematic reviews to assess the role of nonsurgical treatment options in patients with neuroendocrine liver metastases. CONCLUSIONS: These systematic reviews, performed according to this protocol, will assess the value of noninvasive therapy options for patients with nonresectable liver metastases of NETs in combination with invasive techniques, such as percutaneous liver-directed techniques and local ablation techniques. TRIAL REGISTRATION: International Prospective Register of Systematic Reviews (PROSPERO): CRD42012002657; http://www.metaxis.com/PROSPERO/full_doc.asp?RecordID=2657 (Archived by WebCite at http://www.webcitation.org/6NDlYi37O); CRD42012002658; http://www.metaxis.com/PROSPERO/full_doc.asp?RecordID=2658 (Archived by WebCite at http://www.webcitation.org/6NDlfWSuD); CRD42012002659; www.metaxis.com/PROSPERO/full_doc.asp?RecordID=2659 (Arichived by Webcite at http://www.webcitation.org/6NDlmWAFM); and CRD42012002660; http://www.metaxis.com/PROSPERO/full_doc.asp?RecordID=2660 (Archived by WebCite at http://www.webcitation.org/6NDmnylzp).
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spelling pubmed-39618062014-03-21 Nonsurgical Strategies in Patients With NET Liver Metastases: A Protocol of Four Systematic Reviews Limani, Perparim Tschuor, Christoph Gort, Laura Balmer, Bettina Gu, Alexander Ceresa, Christos Raptis, Dimitri Aristotle Lesurtel, Mickael Puhan, Milo Breitenstein, Stefan JMIR Res Protoc Protocol BACKGROUND: Patients diagnosed with neuroendocrine tumors (NETs) with hepatic metastases generally have a worse prognosis as compared with patients with nonmetastasized NETs. Due to tumor location and distant metastases, a surgical approach is often not possible and nonsurgical therapeutic strategies may apply. OBJECTIVE: The aim of these systematic reviews is to evaluate the role of nonsurgical therapy options for patients with nonresectable liver metastases of NETs. METHODS: An objective group of librarians will provide an electronic search strategy to examine the MEDLINE, EMBASE, and The Cochrane Library (Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, Cochrane Central Register of Controlled Trials [CENTRAL]) databases. There will be no restriction concerning language and publication date. The qualitative and quantitative synthesis of the systematic review will be conducted with randomized controlled trials (RCT), prospective, and retrospective comparative cohort, and case-control studies. Case series will be collected in a separate database and only used for descriptive purposes. RESULTS: This study is ongoing and presents a protocol of four systematic reviews to assess the role of nonsurgical treatment options in patients with neuroendocrine liver metastases. CONCLUSIONS: These systematic reviews, performed according to this protocol, will assess the value of noninvasive therapy options for patients with nonresectable liver metastases of NETs in combination with invasive techniques, such as percutaneous liver-directed techniques and local ablation techniques. TRIAL REGISTRATION: International Prospective Register of Systematic Reviews (PROSPERO): CRD42012002657; http://www.metaxis.com/PROSPERO/full_doc.asp?RecordID=2657 (Archived by WebCite at http://www.webcitation.org/6NDlYi37O); CRD42012002658; http://www.metaxis.com/PROSPERO/full_doc.asp?RecordID=2658 (Archived by WebCite at http://www.webcitation.org/6NDlfWSuD); CRD42012002659; www.metaxis.com/PROSPERO/full_doc.asp?RecordID=2659 (Arichived by Webcite at http://www.webcitation.org/6NDlmWAFM); and CRD42012002660; http://www.metaxis.com/PROSPERO/full_doc.asp?RecordID=2660 (Archived by WebCite at http://www.webcitation.org/6NDmnylzp). JMIR Publications Inc. 2014-03-07 /pmc/articles/PMC3961806/ /pubmed/24610518 http://dx.doi.org/10.2196/resprot.2893 Text en ©Perparim Limani, Christoph Tschuor, Laura Gort, Bettina Balmer, Alexander Gu, Christos Ceresa, Dimitri Aristotle Raptis, Mickael Lesurtel, Milo Puhan, Stefan Breitenstein. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 07.03.2014. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Research Protocols, is properly cited. The complete bibliographic information, a link to the original publication on http://www.researchprotocols.org, as well as this copyright and license information must be included.
spellingShingle Protocol
Limani, Perparim
Tschuor, Christoph
Gort, Laura
Balmer, Bettina
Gu, Alexander
Ceresa, Christos
Raptis, Dimitri Aristotle
Lesurtel, Mickael
Puhan, Milo
Breitenstein, Stefan
Nonsurgical Strategies in Patients With NET Liver Metastases: A Protocol of Four Systematic Reviews
title Nonsurgical Strategies in Patients With NET Liver Metastases: A Protocol of Four Systematic Reviews
title_full Nonsurgical Strategies in Patients With NET Liver Metastases: A Protocol of Four Systematic Reviews
title_fullStr Nonsurgical Strategies in Patients With NET Liver Metastases: A Protocol of Four Systematic Reviews
title_full_unstemmed Nonsurgical Strategies in Patients With NET Liver Metastases: A Protocol of Four Systematic Reviews
title_short Nonsurgical Strategies in Patients With NET Liver Metastases: A Protocol of Four Systematic Reviews
title_sort nonsurgical strategies in patients with net liver metastases: a protocol of four systematic reviews
topic Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961806/
https://www.ncbi.nlm.nih.gov/pubmed/24610518
http://dx.doi.org/10.2196/resprot.2893
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