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Late effects of treatment in survivors of childhood cancer from a tertiary cancer center in South India
BACKGROUND: Improved survival after childhood cancer is attributed to intensive, aggressive therapy, adverse sequelae of which can manifest months to years after completion of treatment. There is little information about the late adverse effects of both childhood cancer and its therapy in survivors...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961872/ https://www.ncbi.nlm.nih.gov/pubmed/24665450 http://dx.doi.org/10.4103/2278-330X.126529 |
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author | Rajendranath, Rejiv Veeraiah, Surendran Ramesh, Anita Sagar, Tenali Gnana |
author_facet | Rajendranath, Rejiv Veeraiah, Surendran Ramesh, Anita Sagar, Tenali Gnana |
author_sort | Rajendranath, Rejiv |
collection | PubMed |
description | BACKGROUND: Improved survival after childhood cancer is attributed to intensive, aggressive therapy, adverse sequelae of which can manifest months to years after completion of treatment. There is little information about the late adverse effects of both childhood cancer and its therapy in survivors in India. AIM: To determine the long-term sequelae associated with therapy in childhood cancer survivors attending a tertiary cancer center in India. MATERIALS AND METHODS: We studied 155 consecutive survivors of childhood cancer who were ≤14 years at the time of diagnosis and had completed 3 years of follow-up. The study included a complete history and clinical examination, with specific investigations to detect organ toxicity. Quality of life (QOL) was assessed from responses to a standardized questionnaire. Neurocognitive assessment was carried out in 20 survivors with an adaptation of the revised Wechsler adult intelligence scale for adults and the Malins intelligence scale for children. RESULTS: The late effects included impaired fertility in 38 patients (24.5%), impaired growth pattern in 7 (4.5%), endocrine dysfunction in 7 (4.5%) and second malignancy in 2 (1.2%). Three of the 20 patients assessed had severe neurocognitive impairment. A high QOL was reported by 60% of survivors and an “average” QOL by 38%. CONCLUSION: Our study showed that most survivors had a good QOL and our results will help clinicians to better monitor childhood cancer survivors in countries with limited resources. |
format | Online Article Text |
id | pubmed-3961872 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-39618722014-03-24 Late effects of treatment in survivors of childhood cancer from a tertiary cancer center in South India Rajendranath, Rejiv Veeraiah, Surendran Ramesh, Anita Sagar, Tenali Gnana South Asian J Cancer PEDIATRIC SECTION: Original Article BACKGROUND: Improved survival after childhood cancer is attributed to intensive, aggressive therapy, adverse sequelae of which can manifest months to years after completion of treatment. There is little information about the late adverse effects of both childhood cancer and its therapy in survivors in India. AIM: To determine the long-term sequelae associated with therapy in childhood cancer survivors attending a tertiary cancer center in India. MATERIALS AND METHODS: We studied 155 consecutive survivors of childhood cancer who were ≤14 years at the time of diagnosis and had completed 3 years of follow-up. The study included a complete history and clinical examination, with specific investigations to detect organ toxicity. Quality of life (QOL) was assessed from responses to a standardized questionnaire. Neurocognitive assessment was carried out in 20 survivors with an adaptation of the revised Wechsler adult intelligence scale for adults and the Malins intelligence scale for children. RESULTS: The late effects included impaired fertility in 38 patients (24.5%), impaired growth pattern in 7 (4.5%), endocrine dysfunction in 7 (4.5%) and second malignancy in 2 (1.2%). Three of the 20 patients assessed had severe neurocognitive impairment. A high QOL was reported by 60% of survivors and an “average” QOL by 38%. CONCLUSION: Our study showed that most survivors had a good QOL and our results will help clinicians to better monitor childhood cancer survivors in countries with limited resources. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC3961872/ /pubmed/24665450 http://dx.doi.org/10.4103/2278-330X.126529 Text en Copyright: © South Asian Journal of Cancer http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | PEDIATRIC SECTION: Original Article Rajendranath, Rejiv Veeraiah, Surendran Ramesh, Anita Sagar, Tenali Gnana Late effects of treatment in survivors of childhood cancer from a tertiary cancer center in South India |
title | Late effects of treatment in survivors of childhood cancer from a tertiary cancer center in South India |
title_full | Late effects of treatment in survivors of childhood cancer from a tertiary cancer center in South India |
title_fullStr | Late effects of treatment in survivors of childhood cancer from a tertiary cancer center in South India |
title_full_unstemmed | Late effects of treatment in survivors of childhood cancer from a tertiary cancer center in South India |
title_short | Late effects of treatment in survivors of childhood cancer from a tertiary cancer center in South India |
title_sort | late effects of treatment in survivors of childhood cancer from a tertiary cancer center in south india |
topic | PEDIATRIC SECTION: Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961872/ https://www.ncbi.nlm.nih.gov/pubmed/24665450 http://dx.doi.org/10.4103/2278-330X.126529 |
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